{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T14:11:33Z","timestamp":1774447893642,"version":"3.50.1"},"reference-count":38,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"5","license":[{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2020,4,16]]},"DOI":"10.1167\/tvst.9.5.9","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T21:06:16Z","timestamp":1587071176000},"page":"9","source":"Crossref","is-referenced-by-count":17,"title":["Assessment of Choroidal Neovascularization Perfusion: A Pilot Study With Laser Speckle Flowgraphy"],"prefix":"10.1167","volume":"9","author":[{"given":"Giacomo","family":"Calzetti","sequence":"first","affiliation":[{"name":"Ophthalmology Unit, University Hospital of Parma, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Mora","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, University Hospital of Parma, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Favilla","sequence":"additional","affiliation":[{"name":"Independent Researcher, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Ottonelli","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, University Hospital of Parma, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Devincenzi","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, University Hospital of Parma, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Carta","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, University Hospital of Parma, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Tedesco","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, University Hospital of Parma, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Mursch-Edlmayr","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kepler University Clinic, Johannes Kepler University, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Garh\u00f6fer","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Gandolfi","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, University Hospital of Parma, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leopold","family":"Schmetterer","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"},{"name":"Singapore Eye Research Institute, Singapore"},{"name":"Nanyang Technological University, Singapore"},{"name":"Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore"},{"name":"Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1016\/S0140-6736(12)60282-7","article-title":"Age-related macular degeneration","volume":"379","author":"Lim","year":"2012","journal-title":"Lancet"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/BF00166603","article-title":"Hemodynamic parameter estimation from ocular fluorescein angiograms","volume":"233","author":"van Stokkum","year":"1995","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1056\/NEJMoa054481","article-title":"Ranibizumab for neovascular age-related macular degeneration","volume":"355","author":"Rosenfeld","year":"2006","journal-title":"N Engl J Med"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1056\/NEJMicm1005605","article-title":"Ranibizumab and bevacizumab for neovascular age-related macular degeneration","volume":"364","author":"CATT Research Group","year":"2011","journal-title":"N Engl J Med"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1016\/j.ophtha.2014.01.034","article-title":"Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration","volume":"121","author":"Jia","year":"2014","journal-title":"Ophthalmology"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.ajo.2015.04.012","article-title":"Optical coherence tomography angiography signs of vascular abnormalization with antiangiogenic therapy for choroidal neovascularization","volume":"160","author":"Spaide","year":"2015","journal-title":"Am J Ophthalmol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1111\/cxo.2019.102.issue-3","article-title":"Future clinical applicability of optical coherence tomography angiography","volume":"102","author":"Chua","year":"2019","journal-title":"Clin Exp Optom"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1038\/eye.2015.80","article-title":"OCT angiography and sequential quantitative analysis of type 2 neovascularization after ranibizumab therapy","volume":"29","author":"Kuehlewein","year":"2015","journal-title":"Eye (Lond)"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.1097\/IAE.0000000000000846","article-title":"Optical coherence tomography angiography of time course of choroidal neovascularization in response to anti-angiogenic treatment","volume":"35","author":"Huang","year":"2015","journal-title":"Retina"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1159\/000433547","article-title":"Optical coherence tomography angiography during follow-up: qualitative and quantitative analysis of mixed type I and II choroidal neovascularization after vascular endothelial growth factor trap therapy","volume":"54","author":"Coscas","year":"2015","journal-title":"Ophthalmic Res"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1097\/IAE.0000000000001145","article-title":"Optical coherence tomography angiography assessment of vascular effects occurring after aflibercept intravitreal injections in treatment-naive patients with wet age-related macular degeneration","volume":"37","author":"Mastropasqua","year":"2017","journal-title":"Retina"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1007\/s004170050058","article-title":"Topical fundus pulsation measurements in age-related macular degeneration","volume":"236","author":"Schmetterer","year":"1998","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1167\/iovs.07-0526","article-title":"Foveolar choroidal circulation and choroidal neovascularization in age-related macular degeneration","volume":"49","author":"Metelitsina","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1111\/aos.2009.87.issue-6","article-title":"Ocular haemodynamic changes after single treatment with photodynamic therapy assessed with non-invasive techniques","volume":"87","author":"Maar","year":"2009","journal-title":"Acta Ophthalmol"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"4220","DOI":"10.1167\/iovs.09-4968","article-title":"Choroidal blood flow and progression of age-related macular degeneration in the fellow eye in patients with unilateral choroidal neovascularization","volume":"51","author":"Boltz","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1111\/aos.2010.88.issue-7","article-title":"Use of laser speckle flowgraphy in ocular blood flow research","volume":"88","author":"Sugiyama","year":"2010","journal-title":"Acta Ophthalmol"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"e0184772","DOI":"10.1371\/journal.pone.0184772","article-title":"Optic nerve head and retinal blood flow regulation during isometric exercise as assessed with laser speckle flowgraphy","volume":"12","author":"Witkowska","year":"2017","journal-title":"PLoS One"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s10384-007-0521-7","article-title":"Imaging of choroidal hemodynamics in eyes with polypoidal choroidal vasculopathy using laser speckle phenomenon","volume":"52","author":"Watanabe","year":"2008","journal-title":"Jpn J Ophthalmol"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.preteyeres.2016.04.002","article-title":"Age-related macular degeneration and polypoidal choroidal vasculopathy in Asians","volume":"53","author":"Wong","year":"2016","journal-title":"Prog Retin Eye Res"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"220","DOI":"10.3390\/photonics1030220","article-title":"Basic technology and clinical applications of the updated model of laser speckle flowgraphy to ocular diseases","volume":"1","author":"Sugiyama","year":"2014;","journal-title":"Photonics"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"OCT307","DOI":"10.1167\/iovs.15-18830","article-title":"Type 1 choroidal neovascularization lesion size: indocyanine green angiography versus optical coherence tomography angiography","volume":"57","author":"Costanzo","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.1167\/iovs.17-22902","article-title":"Comparison of SD-optical coherence tomography angiography and indocyanine green angiography in type 1 and 2 neovascular age-related macular degeneration","volume":"59","author":"Told","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/S0021-5155(01)00498-1","article-title":"Effects of caffeine on microcirculation of the human ocular fundus","volume":"46","author":"Okuno","year":"2000","journal-title":"Jpn J Ophthalmol"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"e519","DOI":"10.1097\/MD.0000000000000519","article-title":"Diurnal variations in blood flow at optic nerve head and choroid in healthy eyes: diurnal variations in blood flow","volume":"94","author":"Iwase","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1136\/bjophthalmol-2017-311750","article-title":"Assessment of choroidal blood flow using laser speckle flowgraphy","volume":"102","author":"Calzetti","year":"2018","journal-title":"Br J Ophthalmol"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"3899","DOI":"10.1167\/iovs.14-14116","article-title":"Relative flow volume, a novel blood flow index in the human retina derived from laser speckle flowgraphy","volume":"55","author":"Shiga","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1037\/1040-3590.6.4.284","article-title":"Guidelines, criteria, and rules of thumb for evaluating normed and standardized assessment instruments in psychology","volume":"6","author":"Cicchetti","year":"1994","journal-title":"Psychol Assess"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1001\/archopht.121.2.225","article-title":"Observation of choroidal circulation using index of erythrocytic velocity","volume":"121","author":"Isono","year":"2003","journal-title":"Arch Ophthalmol"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0014-4835(73)90185-1","article-title":"Ocular and optic nerve blood flow at normal and increased intraocular pressures in monkeys (Macaca irus): a study with radioactively labelled microspheres including flow determinations in brain and some other tissues","volume":"15","author":"Alm","year":"1973","journal-title":"Exp Eye Res"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1136\/bjophthalmol-2012-302349","article-title":"Macular choroidal blood flow velocity decreases with regression of acute central serous chorioretinopathy","volume":"97","author":"Saito","year":"2013","journal-title":"Br J Ophthalmol"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1167\/iovs.17-23050","article-title":"Relations among foveal blood flow, retinal-choroidal structure, and visual function in retinitis pigmentosa","volume":"59","author":"Murakami","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"14128","DOI":"10.1038\/s41598-018-32487-y","article-title":"A randomized clinical trial evaluating choroidal blood flow and morphology after conventional and pattern scan laser panretinal photocoagulation","volume":"8","author":"Mikoshiba","year":"2018","journal-title":"Sci Rep"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"7400","DOI":"10.1167\/iovs.10-6646","article-title":"The effect of intravitreal injection of bevacizumab on retinal circulation in patients with neovascular macular degeneration","volume":"52","author":"Fontaine","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1016\/j.ophtha.2009.03.017","article-title":"Intravitreal ranibizumab may induce retinal arteriolar vasoconstriction in patients with neovascular age-related macular degeneration","volume":"116","author":"Papadopoulou","year":"2009","journal-title":"Ophthalmology"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"37","DOI":"10.2147\/OPTH","article-title":"The effect of intravitreal bevacizumab (Avastin) on ocular pulse amplitude in neovascular age-related macular degeneration","volume":"5","author":"Rechtman","year":"2011","journal-title":"Clin Ophthalmol"},{"key":"bib36","first-page":"1119","article-title":"The effect of intravitreal bevacizumab on ocular blood flow in diabetic retinopathy and branch retinal vein occlusion as measured by laser speckle flowgraphy","volume":"8","author":"Nitta","year":"2014","journal-title":"Clin Ophthalmol"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1007\/s00417-018-3939-3","article-title":"Effects of intravitreal injection of ranibizumab on choroidal structure and blood flow in eyes with diabetic macular edema","volume":"256","author":"Okamoto","year":"2018","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"e783","DOI":"10.1111\/aos.2018.96.issue-7","article-title":"Choroidal blood flow after the first intravitreal ranibizumab injection in neovascular age-related macular degeneration patients","volume":"96","author":"Mottet","year":"2018","journal-title":"Acta Ophthalmol"}],"container-title":["Translational Vision Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2764779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T21:06:18Z","timestamp":1587071178000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2764779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,16]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,4,9]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.9.5.9","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4,16]]}}}