{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:00:05Z","timestamp":1790712005584,"version":"4.1.0"},"reference-count":37,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"6","license":[{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2020,5,20]]},"DOI":"10.1167\/tvst.9.6.20","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T20:31:57Z","timestamp":1590006717000},"page":"20","source":"Crossref","is-referenced-by-count":32,"title":["Intraocular Distribution and Kinetics of Intravitreally Injected Antibodies and Nanoparticles in Rabbit Eyes"],"prefix":"10.1167","volume":"9","author":[{"given":"Hyeong Min","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungmin","family":"Ha","sequence":"additional","affiliation":[{"name":"Seoul Eye Clinic, Daegu, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Kyoung","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoonha","family":"Hwang","sequence":"additional","affiliation":[{"name":"Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea"},{"name":"KI for Health Science and Technology (KIHST), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilhan","family":"Kim","sequence":"additional","affiliation":[{"name":"Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea"},{"name":"KI for Health Science and Technology (KIHST), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea"},{"name":"Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunsol","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Bundang Hospital,Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Yong","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Bundang Hospital,Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunyoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Joo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Hyung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuncheol","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Joon","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1056\/NEJMoa054481","article-title":"Ranibizumab for neovascular age-related macular degeneration","volume":"355","author":"Rosenfeld","year":"2006","journal-title":"N Engl J Med"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1097\/ICU.0b013e3282f0ca54","article-title":"Anti-vascular endothelial growth factor therapy for ocular neovascular disease","volume":"18","author":"Andreoli","year":"2007","journal-title":"Curr Opin Ophthalmol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1016\/j.ophtha.2011.02.022","article-title":"Sustained benefits from ranibizumab for macular edema following branch retinal vein occlusion: 12-month outcomes of a phase III study","volume":"118","author":"Brown","year":"2011","journal-title":"Ophthalmology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1016\/j.ophtha.2010.02.022","article-title":"Ranibizumab for macular edema following central retinal vein occlusion: six-month primary end point results of a phase III study","volume":"117","author":"Brown","year":"2010","journal-title":"Ophthalmology"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1016\/j.ophtha.2011.02.038","article-title":"Sustained benefits from ranibizumab for macular edema following central retinal vein occlusion: twelve-month outcomes of a phase III study","volume":"118","author":"Campochiaro","year":"2011","journal-title":"Ophthalmology"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1097\/01.iae.0000242842.14624.e7","article-title":"Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration","volume":"26","author":"Ferrara","year":"2006","journal-title":"Retina"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1097\/IAE.0b013e318134eecd","article-title":"Pharmacokinetics and retinal distribution of ranibizumab, a humanized antibody fragment directed against VEGF-A, following intravitreal administration in rabbits","volume":"27","author":"Gaudreault","year":"2007","journal-title":"Retina"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"4807","DOI":"10.1167\/iovs.08-3148","article-title":"Pharmacokinetics of bevacizumab after topical, subconjunctival, and intravitreal administration in rabbits","volume":"50","author":"Nomoto","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"697","DOI":"10.2147\/OPTH","article-title":"Pharmacokinetics of intravitreal bevacizumab (Avastin(R)) in rabbits","volume":"5","author":"Sinapis","year":"2011","journal-title":"Clin Ophthalmol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1159\/000499529","article-title":"A prediction model for the intraocular pharmacokinetics of intravitreally injected drugs based on molecular physicochemical properties","volume":"63","author":"Kim","year":"2019","journal-title":"Ophthalmic Res"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1021\/acs.molpharmaceut.7b00164","article-title":"Ocular pharmacokinetics of therapeutic antibodies given by intravitreal injection: estimation of retinal permeabilities using a 3-compartment semi-mechanistic model","volume":"14","author":"Hutton-Smith","year":"2017","journal-title":"Mol Pharm"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1016\/j.ophtha.2007.09.012","article-title":"Pharmacokinetics of intravitreal ranibizumab (Lucentis)","volume":"114","author":"Bakri","year":"2007","journal-title":"Ophthalmology"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.ophtha.2007.01.017","article-title":"Pharmacokinetics of intravitreal bevacizumab (Avastin)","volume":"114","author":"Bakri","year":"2007","journal-title":"Ophthalmology"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"3162","DOI":"10.1167\/iovs.09-4697","article-title":"Physicochemical properties affecting retinal drug\/coumarin-6 delivery from nanocarrier systems via eyedrop administration","volume":"51","author":"Inokuchi","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib15","first-page":"150","article-title":"Effect of circulation on the disposition and ocular tissue distribution of 20 nm nanoparticles after periocular administration","volume":"14","author":"Amrite","year":"2008","journal-title":"Mol Vis"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1159\/000055638","article-title":"Effect of particle size of polymeric nanospheres on intravitreal kinetics","volume":"33","author":"Sakurai","year":"2001","journal-title":"Ophthalmic Res"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1089\/jop.2013.0009","article-title":"Pharmacokinetics of intravitreally injected bevacizumab in vitrectomized eyes","volume":"29","author":"Ahn","year":"2013","journal-title":"J Ocul Pharmacol Ther"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1167\/iovs.13-13054","article-title":"Intraocular pharmacokinetics of ranibizumab in vitrectomized versus nonvitrectomized eyes","volume":"55","author":"Ahn","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"6501","DOI":"10.1167\/iovs.15-17279","article-title":"Ranibizumab and aflibercept: intraocular pharmacokinetics and their effects on aqueous VEGF level in vitrectomized and nonvitrectomized Macaque eyes","volume":"56","author":"Niwa","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/eye.2014.329","article-title":"Intraocular pharmacokinetics of intravitreal vascular endothelial growth factor-Trap in a rabbit model","volume":"29","author":"Park","year":"2015","journal-title":"Eye (Lond)"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.1167\/iovs.16-19204","article-title":"Intraocular pharmacokinetics of intravitreal aflibercept (Eylea) in a rabbit model","volume":"57","author":"Park","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"4261","DOI":"10.1167\/iovs.17-21813","article-title":"Role of the Fc region in the vitreous half-life of anti-VEGF drugs","volume":"58","author":"Joo","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"11465","DOI":"10.1364\/OE.22.011465","article-title":"In vivo analysis of THz wave irradiation induced acute inflammatory response in skin by laser-scanning confocal microscopy","volume":"22","author":"Hwang","year":"2014","journal-title":"Opt Express"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"4042","DOI":"10.1172\/JCI76509","article-title":"Intravital imaging of intestinal lacteals unveils lipid drainage through contractility","volume":"125","author":"Choe","year":"2015","journal-title":"J Clin Invest"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1002\/med.21509","article-title":"Gold nanoparticles in ophthalmology","volume":"39","author":"Masse","year":"2019","journal-title":"Med Res Rev"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.jconrel.2005.03.010","article-title":"Evaluation of coupled convective-diffusive transport of drugs administered by intravitreal injection and controlled release implant","volume":"105","author":"Park","year":"2005","journal-title":"J Control Release"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.preteyeres.2010.04.003","article-title":"Intravitreal therapy for neovascular age-related macular degeneration and inter-individual variations in vitreous pharmacokinetics","volume":"29","author":"Laude","year":"2010","journal-title":"Prog Retin Eye Res"},{"key":"bib28","first-page":"429","article-title":"[Studies on the ultrastructure of the inner limiting membrane of the retina. I. Surface replication study on the inner limiting membrane of the retina]","volume":"93","author":"Nishihara","year":"1989","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"bib29","first-page":"951","article-title":"[Studies on the ultrastructure of the inner limiting membrane of the retina\u2013distribution of anionic sites in the inner limiting membrane of the retina]","volume":"95","author":"Nishihara","year":"1991","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"5978","DOI":"10.1016\/j.biomaterials.2013.04.035","article-title":"Hyaluronan-modified core-shell liponanoparticles targeting CD44-positive retinal pigment epithelium cells via intravitreal injection","volume":"34","author":"Gan","year":"2013","journal-title":"Biomaterials"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1021\/acs.molpharmaceut.6b01029","article-title":"Hyaluronic acid coated albumin nanoparticles for targeted peptide delivery to the retina","volume":"14","author":"Huang","year":"2017","journal-title":"Mol Pharm"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jconrel.2015.01.030","article-title":"Coating nanocarriers with hyaluronic acid facilitates intravitreal drug delivery for retinal gene therapy","volume":"202","author":"Martens","year":"2015","journal-title":"J Control Release"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.2217\/nnm.12.202","article-title":"Measuring the intravitreal mobility of nanomedicines with single-particle tracking microscopy","volume":"8","author":"Martens","year":"2013","journal-title":"Nanomedicine (Lond)"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"3553","DOI":"10.1167\/iovs.05-0165","article-title":"Vitreous: a barrier to nonviral ocular gene therapy","volume":"46","author":"Peeters","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1016\/j.bpj.2015.10.002","article-title":"Diffusion regulation in the vitreous humor","volume":"109","author":"Kasdorf","year":"2015","journal-title":"Biophys J"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"3485","DOI":"10.1016\/j.biomaterials.2012.01.030","article-title":"The movement of self-assembled amphiphilic polymeric nanoparticles in the vitreous and retina after intravitreal injection","volume":"33","author":"Koo","year":"2012","journal-title":"Biomaterials"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"107711","DOI":"10.1016\/j.exer.2019.107711","article-title":"Investigating impacts of surface charge on intraocular distribution of intravitreal lipid nanoparticles","volume":"186","author":"Huang","year":"2019","journal-title":"Exp Eye Res"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2766227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T20:31:59Z","timestamp":1590006719000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2766227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,20]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,5,11]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.9.6.20","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5,20]]}}}