{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:08:56Z","timestamp":1791655736651,"version":"4.3.4"},"reference-count":39,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"6","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2020,5,11]]},"DOI":"10.1167\/tvst.9.6.6","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T23:53:23Z","timestamp":1589241203000},"page":"6","source":"Crossref","is-referenced-by-count":12,"title":["Biofeedback Rehabilitation and Visual Cortex Response in Stargardt's Disease: A Randomized Controlled Trial"],"prefix":"10.1167","volume":"9","author":[{"given":"Paolo","family":"Melillo","sequence":"first","affiliation":[{"name":"Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania Luigi Vanvitelli, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Prinster","sequence":"additional","affiliation":[{"name":"Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Di Iorio","sequence":"additional","affiliation":[{"name":"Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania Luigi Vanvitelli, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Olivo","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Maria","family":"D'Alterio","sequence":"additional","affiliation":[{"name":"Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania Luigi Vanvitelli, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirio","family":"Cocozza","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Quarantelli","sequence":"additional","affiliation":[{"name":"Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Testa","sequence":"additional","affiliation":[{"name":"Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania Luigi Vanvitelli, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Brunetti","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Simonelli","sequence":"additional","affiliation":[{"name":"Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania Luigi Vanvitelli, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.ophtha.2015.12.009","article-title":"The Natural History of the Progression of Atrophy Secondary to Stargardt Disease (ProgStar) studies: design and baseline characteristics: ProgStar report no. 1","volume":"123","author":"Strauss","year":"2016","journal-title":"Ophthalmology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/ng0397-236","article-title":"A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy","volume":"15","author":"Allikmets","year":"1997","journal-title":"Nat Genet"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/0002-9394(62)91987-6","article-title":"Phenomenology of eccentric fixation","volume":"53","author":"Von Noorden","year":"1962","journal-title":"Am J Ophthalmol"},{"key":"bib4","first-page":"268","article-title":"Eccentric fixation with macular scotoma","volume":"29","author":"Whittaker","year":"1988","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/S0161-6420(87)33533-X","article-title":"Visual acuity loss in patients with Stargardt's macular dystrophy","volume":"94","author":"Fishman","year":"1987","journal-title":"Ophthalmology"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1001\/archopht.1979.01020020023005","article-title":"Stargardt's disease and fundus flavimaculatus","volume":"97","author":"Noble","year":"1979","journal-title":"Arch Ophthalmol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/S0161-6420(03)00333-6","article-title":"Visual acuity loss and clinical observations in a large series of patients with Stargardt disease","volume":"110","author":"Rotenstreich","year":"2003","journal-title":"Ophthalmology"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1016\/j.ophtha.2006.04.027","article-title":"Comparison of visual acuity loss in patients with different stages of Stargardt's disease","volume":"113","author":"Kim","year":"2006","journal-title":"Ophthalmology"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1016\/j.ophtha.2005.03.027","article-title":"Preferred retinal locus development in patients with macular disease","volume":"112","author":"Crossland","year":"2005","journal-title":"Ophthalmology"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1155\/2016\/4264829","article-title":"Fixation improvement through biofeedback rehabilitation in Stargardt disease","volume":"2016","author":"Scuderi","year":"2016","journal-title":"Case Rep Med"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s10484-009-9083-4","article-title":"Low-vision rehabilitation by means of MP-1 biofeedback examination in patients with different macular diseases: a pilot study","volume":"34","author":"Vingolo","year":"2009","journal-title":"Appl Psychophysiol Biofeedback"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/PL00007988","article-title":"Simulation of plasticity in the adult visual cortex","volume":"84","author":"Andrade","year":"2001","journal-title":"Biol Cybern"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1016\/S0042-6989(00)00059-6","article-title":"The importance of sustained attention for patients with maculopathies","volume":"40","author":"Altpeter","year":"2000","journal-title":"Vision Res"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s10827-006-6358-0","article-title":"Attentional modulation of firing rate and synchrony in a model cortical network","volume":"20","author":"Buia","year":"2006","journal-title":"J Comput Neurosci"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1097\/IAE.0000000000002151","article-title":"Association between genotype and disease progression in Italian Stargardt patients: a retrospective natural history study","volume":"39","author":"Di Iorio","year":"2019","journal-title":"Retina"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1001\/archopht.1976.03910040721003","article-title":"Fundus flavimaculatus. A clinical classification","volume":"94","author":"Fishman","year":"1976","journal-title":"Arch Ophthalmol"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1097\/IAE.0b013e3181bd2c3b","article-title":"Comparison of spectral\/Fourier domain optical coherence tomography instruments for assessment of normal macular thickness","volume":"30","author":"Sull","year":"2010","journal-title":"Retina"},{"key":"bib18","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.ophtha.2010.11.013","article-title":"Spectral domain optical coherence tomography imaging of drusen in nonexudative age-related macular degeneration","volume":"118","author":"Gregori","year":"2011","journal-title":"Ophthalmology"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"OCT247","DOI":"10.1167\/iovs.15-18751","article-title":"En face spectral-domain optical coherence tomography for the monitoring of lesion area progression in Stargardt disease","volume":"57","author":"Melillo","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1016\/S0161-6420(02)01120-X","article-title":"Patient selection for macular translocation surgery using the scanning laser ophthalmoscope","volume":"109","author":"Fujii","year":"2002","journal-title":"Ophthalmology"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1097\/IAE.0b013e3181e46af3","article-title":"Nidek MP1 is able to detect subtle decline in function in inherited and age-related atrophic macular disease with stable visual acuity","volume":"31","author":"Chen","year":"2011","journal-title":"Retina"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10633-014-9473-7","article-title":"ISCEV Standard for full-field clinical electroretinography (2015 update)","volume":"130","author":"McCulloch","year":"2015","journal-title":"Doc Ophthalmol"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1001\/archopht.119.3.359","article-title":"Phenotypic subtypes of Stargardt macular dystrophy-fundus flavimaculatus","volume":"119","author":"Lois","year":"2001","journal-title":"Arch Ophthalmol"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"6153","DOI":"10.1167\/iovs.11-8375","article-title":"Reproducibility of activation maps for longitudinal studies of visual function by functional magnetic resonance imaging","volume":"53","author":"Ming","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1006\/nimg.1995.1007","article-title":"Analysis of fMRI time-series revisited","volume":"2","author":"Friston","year":"1995","journal-title":"Neuroimage"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1006\/nimg.1997.0290","article-title":"Multimodal image coregistration and partitioning\u2013a unified framework","volume":"6","author":"Ashburner","year":"1997","journal-title":"Neuroimage"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1016\/j.neuroimage.2011.02.055","article-title":"Gray matter alterations in visual cortex of patients with loss of central vision due to hereditary retinal dystrophies","volume":"56","author":"Plank","year":"2011","journal-title":"Neuroimage"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.visres.2010.08.004","article-title":"Imaging retinotopic maps in the human brain","volume":"51","author":"Wandell","year":"2011","journal-title":"Vision Res"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.2307\/2531734","article-title":"Models for longitudinal data: a generalized estimating equation approach","volume":"44","author":"Zeger","year":"1988","journal-title":"Biometrics"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"7388","DOI":"10.1167\/iovs.15-16899","article-title":"Cerebral involvement in stargardt's disease: a VBM and TBSS study","volume":"56","author":"Olivo","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.cortex.2013.01.003","article-title":"Morphometric analyses of the visual pathways in macular degeneration","volume":"56","author":"Hernowo","year":"2014","journal-title":"Cortex"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1093\/cercor\/bhm256","article-title":"V1 projection zone signals in human macular degeneration depend on task, not stimulus","volume":"18","author":"Masuda","year":"2008","journal-title":"Cereb Cortex"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1523\/JNEUROSCI.5258-08.2009","article-title":"Reorganization of visual processing in macular degeneration is not specific to the \u201cpreferred retinal locus\u201d","volume":"29","author":"Dilks","year":"2009","journal-title":"J Neurosci"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1523\/JNEUROSCI.3476-04.2005","article-title":"Reorganization of visual processing in macular degeneration","volume":"25","author":"Baker","year":"2005","journal-title":"J Neurosci"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/nn.2793","article-title":"Large-scale remapping of visual cortex is absent in adult humans with macular degeneration","volume":"14","author":"Baseler","year":"2011","journal-title":"Nat Neurosci"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1167\/iovs.17-22900","article-title":"Visual cortex activation in patients with Stargardt disease","volume":"59","author":"Melillo","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"723","DOI":"10.5301\/ejo.5000291","article-title":"Biofeedback rehabilitation of eccentric fixation in patients with Stargardt disease","volume":"23","author":"Verdina","year":"2013","journal-title":"Eur J Ophthalmol"},{"key":"bib39","first-page":"379","article-title":"Biofeedback treatment in medicine and psychiatry: an ultimate placebo?","volume":"5","author":"Stroebel","year":"1973","journal-title":"Semin Psychiatry"},{"key":"bib30","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-981-10-3794-8_12","article-title":"Generalized estimating equation","volume-title":"Analysis of repeated measures data","author":"Islam","year":"2017"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2766030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T22:58:29Z","timestamp":1696114709000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2766030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,11]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,5,11]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.9.6.6","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5,11]]}}}