{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T14:01:21Z","timestamp":1769695281315,"version":"3.49.0"},"reference-count":40,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"8","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2020,7,22]]},"DOI":"10.1167\/tvst.9.8.33","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T15:32:13Z","timestamp":1595431933000},"page":"33","source":"Crossref","is-referenced-by-count":16,"title":["PnPP-19 Peptide as a Novel Drug Candidate for Topical Glaucoma Therapy Through Nitric Oxide Release"],"prefix":"10.1167","volume":"9","author":[{"given":"Carolina Nunes","family":"da Silva","sequence":"first","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais,Belo Horizonte-MG, Zipcode 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lays Fernanda Nunes","family":"Dourado","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais,Belo Horizonte-MG, Zipcode 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Elena","family":"de Lima","sequence":"additional","affiliation":[{"name":"Santa Casa de Belo Horizonte: Instituto de Ensino e Pesquisa, Belo Horizonte-MG, Zipcode 30150-240, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"da Silva Cunha-Jr","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais,Belo Horizonte-MG, Zipcode 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1016\/S0140-6736(04)16257-0","article-title":"Primary open-angle glaucoma","volume":"363P","author":"Weinreb","year":"2004","journal-title":"Lancet"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.preteyeres.2011.11.002","article-title":"The molecular basis of retinal ganglion cell death in glaucoma","volume":"31","author":"Almasieh","year":"2012","journal-title":"Prog Retin Eye Res"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: A systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s40123-017-0094-6","article-title":"A review of nitric oxide for the treatment of glaucomatous disease","volume":"6","author":"Aliancy","year":"2017","journal-title":"Ophthalmol Ther"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/S1350-9462(03)00064-8","article-title":"The effects of antiglaucoma and systemic medications on ocular blood flow","volume":"22","author":"Costa","year":"2003","journal-title":"Prog Retin Eye Res"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.exer.2015.05.012","article-title":"Modeling glaucoma in rats by sclerosing aqueous outflow pathways to elevate intraocular pressure","volume":"141","author":"Morrison","year":"2015","journal-title":"Exp Eye Res"},{"key":"bib8","first-page":"751","article-title":"Limbal microvasculature of the rat eye","volume":"36","author":"Morrison","year":"1995","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"Pt B","key":"bib9","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.ejpb.2015.04.029","article-title":"The aqueous humor outflow pathways in glaucoma: a unifying concept of disease mechanisms and causative treatment","volume":"95","author":"Braunger","year":"2015","journal-title":"Eur J Pharm Biopharm"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1006\/exer.1996.0184","article-title":"A rat model of chronic pressure-induced optic nerve damage","volume":"64","author":"Morrison","year":"1997","journal-title":"Exp Eye Res"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/S0014-4835(05)80131-9","article-title":"Chronic ocular hypertension following episcleral venous occlusion in rats","volume":"61","author":"Shareef","year":"1995","journal-title":"Exp Eye Res"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.exer.2005.01.008","article-title":"A new experimental model of glaucoma in rats through intracameral injections of hyaluronic acid","volume":"81","author":"Moreno","year":"2005","journal-title":"Exp Eye Res"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The pathophysiology and treatment of glaucoma: a review","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMA"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1016\/j.drudis.2019.05.033","article-title":"Nitric oxide: a drug target for glaucoma revisited","volume":"24","author":"Garh\u00f6fer","year":"2019","journal-title":"Drug Discov Today"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"5005","DOI":"10.1167\/iovs.14-14515","article-title":"Nitric oxide (NO): an emerging target for the treatment of glaucoma","volume":"55","author":"Cavet","year":"2014","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.niox.2018.04.010","article-title":"The nitric oxide-guanylate cyclase pathway and glaucoma","volume":"77","author":"Wareham","year":"2018","journal-title":"Nitric Oxide"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1006\/exer.1994.1199","article-title":"Nitrovasodilator effects on intraocular pressure and outflow facility in monkeys","volume":"58","author":"Schuman","year":"1994","journal-title":"Exp Eye Res"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3109\/02713689609017615","article-title":"Short-term hemodynamic changes in episcleral arteriovenous anastomoses correlate with venous pressure and IOP changes in the Albino rabbit","volume":"15","author":"Funk","year":"1996","journal-title":"Curr Eye Res"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.addr.2018.01.008","article-title":"Ocular delivery of proteins and peptides: challenges and novel formulation approaches","volume":"126","author":"Mandal","year":"2018","journal-title":"Adv Drug Deliv Rev"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1016\/j.juro.2015.06.081","article-title":"PnPP-19, a synthetic and nontoxic peptide designed from a phoneutria nigriventer toxin, potentiates erectile function via NO\/cGMP","volume":"194","author":"Silva","year":"2015","journal-title":"J Urol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/0887-2333(96)00021-5","article-title":"Evaluation of a modified HET-CAM assay as a screening test for eye irritancy","volume":"10","author":"Gilleron","year":"1996","journal-title":"Toxicol Vitr"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"203","DOI":"10.3390\/toxins11040203","article-title":"A new topical eye drop containing LyeTxI-b, a synthetic peptide designed from a lycosa erithrognata venom toxin, was effective to treat resistant bacterial keratitis","volume":"11","author":"da Silva","year":"2019","journal-title":"Toxins (Basel)"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10633-014-9473-7","article-title":"ISCEV standard for full-field clinical electroretinography (2015 update)","volume":"130","author":"McCulloch","year":"2015","journal-title":"Doc Ophthalmol Ophthalmol"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s10633-019-09682-x","article-title":"Corosolic acid: antiangiogenic activity and safety of intravitreal injection in rats eyes","volume":"138","author":"Toledo","year":"2019","journal-title":"Doc Ophthalmol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1136\/bjo.67.7.443","article-title":"Relationship between the amplitudes of the b wave and the a wave as a useful index for evaluating the electroretinogram","volume":"67","author":"Perlman","year":"1983","journal-title":"Br J Ophthalmol"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/0042-6989(68)90041-2","article-title":"The electroretinogram: its components and their origins","volume":"8","author":"Brown","year":"1968","journal-title":"Vision Res"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"e95461","DOI":"10.1371\/journal.pone.0095461","article-title":"Bimatoprost-loaded ocular inserts as sustained release drug delivery systems for glaucoma treatment: in vitro and in vivo evaluation","volume":"9","author":"Franca","year":"2014","journal-title":"PLoS One"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal Biochem"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.niox.2017.01.004","article-title":"The synthetic peptide PnPP-19 induces peripheral antinociception via activation of NO\/cGMP\/KATP pathway: role of eNOS and nNOS","volume":"64","author":"Freitas","year":"2017","journal-title":"Nitric Oxide"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1016\/S0140-6736(14)62347-3","article-title":"Glaucoma treatment: by the highest level of evidence","volume":"385","author":"Heijl","year":"2015","journal-title":"Lancet"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1016\/j.addr.2007.04.019","article-title":"The chick embryo and its chorioallantoic membrane (CAM) for the in vivo evaluation of drug delivery systems","volume":"59","author":"Vargas","year":"2007","journal-title":"Adv Drug Deliv Rev"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijpharm.2012.04.063","article-title":"Conjunctival and corneal tolerability assessment of ocular naltrexone niosomes and their ingredients on the hen's egg chorioallantoic membrane and excised bovine cornea models","volume":"432","author":"Abdelkader","year":"2012","journal-title":"Int J Pharm"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s10633-008-9153-6","article-title":"Testing retinal toxicity of drugs in animal models using electrophysiological and morphological techniques","volume":"118","author":"Perlman","year":"2009","journal-title":"Doc Ophthalmol"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"e277","DOI":"10.1111\/aos.13568","article-title":"Efficacy and safety of different regimens for primary open-angle glaucoma or ocular hypertension: a systematic review and network meta-analysis","volume":"96","author":"Li","year":"2018","journal-title":"Acta Ophthalmol"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1089\/jop.2016.0188","article-title":"The role of nitric oxide in the intraocular pressure lowering efficacy of latanoprostene bunod: review of nonclinical studies","volume":"34","author":"Cavet","year":"2018","journal-title":"J Ocul Pharmacol Ther"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"8067","DOI":"10.1167\/iovs.14-14722","article-title":"Shear stress-triggered nitric oxide release from Schlemm's canal cells","volume":"55","author":"Ashpole","year":"2014","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"8103","DOI":"10.1073\/pnas.90.17.8103","article-title":"Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine","volume":"90","author":"Ignarro","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"692609","DOI":"10.1155\/2012\/692609","article-title":"Animal models of glaucoma","volume":"2012","author":"Bouhenni","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"bib39","first-page":"2196","article-title":"Effect of hyaluronic acid on intraocular pressure in rats","volume":"43","author":"Benozzi","year":"2002","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.jsxm.2019.01.004","article-title":"PnPP-19 peptide restores erectile function in hypertensive and diabetic animals through intravenous and topical administration","volume":"16","author":"Nunes da Silva","year":"2019","journal-title":"J Sex Med"}],"container-title":["Translational Vision Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2770355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T15:32:18Z","timestamp":1595431938000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2770355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,22]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,7,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.9.8.33","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7,22]]}}}