{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T03:19:53Z","timestamp":1784085593227,"version":"3.55.0"},"reference-count":49,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"8","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2020,7,23]]},"DOI":"10.1167\/tvst.9.8.34","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T15:02:57Z","timestamp":1595516577000},"page":"34","source":"Crossref","is-referenced-by-count":17,"title":["A Reflectivity Measure to Quantify Bruch's Membrane Calcification in Patients with Pseudoxanthoma Elasticum Using Optical Coherence Tomography"],"prefix":"10.1167","volume":"9","author":[{"given":"Sara","family":"Risseeuw","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Bennink","sequence":"additional","affiliation":[{"name":"Image Sciences Institute, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten G.","family":"Poirot","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim A.","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilko","family":"Spiering","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia M.","family":"Imhof","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Redmer","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannette","family":"Ossewaarde-van Norel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/76109","article-title":"Mutations in ABCC6 cause pseudoxanthoma elasticum","volume":"25","author":"Bergen","year":"2000","journal-title":"Nat Genet"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.ejmg.2018.05.020","article-title":"The prevalence of pseudoxanthoma elasticum: revised estimations based on genotyping in a high vascular risk cohort","volume":"62","author":"Kranenburg","year":"2019","journal-title":"Eur J Med Genet"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3389\/fgene.2013.00014","article-title":"An update on the ocular phenotype in patients with pseudoxanthoma elasticum","volume":"4","author":"Gliem","year":"2013","journal-title":"Front Genet"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1097\/IAE.0000000000002173","article-title":"Visual acuity in pseudoxanthoma elasticum","volume":"39","author":"Risseeuw","year":"2019","journal-title":"Retina"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.jacc.2017.12.062","article-title":"Etidronate for prevention of ectopic mineralization in patients with pseudoxanthoma elasticum","volume":"71","author":"Kranenburg","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1097\/IAE.0000000000000420","article-title":"Peau d'orange and angioid streaks: manifestations of Bruch membrane pathology","volume":"35","author":"Spaide","year":"2015","journal-title":"Retina"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"5913","DOI":"10.1167\/iovs.09-3541","article-title":"Multimodal imaging including spectral domain OCT and confocal near infrared reflectance for characterization of outer retinal pathology in pseudoxanthoma elasticum","volume":"50","author":"Charbel Issa","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"6846","DOI":"10.1167\/iovs.13-12062","article-title":"Quantitative analysis of retinal layer optical intensities on three-dimensional optical coherence tomography","volume":"54","author":"Chen","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib9","first-page":"2857","article-title":"Morphometric analysis of Bruch's membrane, the choriocapillaris, and the choroid in aging","volume":"35","author":"Ramrattan","year":"1994","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"3463","DOI":"10.1167\/iovs.12-11484","article-title":"Individual A-scan signal normalization between two spectral domain optical coherence tomography devices","volume":"54","author":"Chen","year":"2013","journal-title":"Investig Opthalmology Vis Sci"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"6102","DOI":"10.1167\/iovs.12-9933","article-title":"RPE-normalized RNFL attenuation coefficient maps derived from volumetric OCT imaging for glaucoma assessment","volume":"53","author":"Vermeer","year":"2012","journal-title":"Investig Opthalmol Vis Sci"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1002\/ajmg.a.v152a:4","article-title":"Proposal for updating the pseudoxanthoma elasticum classification system and a review of the clinical findings","volume":"152","author":"Plomp","year":"2010","journal-title":"Am J Med Genet A"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1109\/TMI.2009.2016958","article-title":"Automated 3-D intraretinal layer segmentation of macular spectral-domain optical coherence tomography images","volume":"28","author":"Garvin","year":"2009","journal-title":"IEEE Trans Med Imaging"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1364\/BOE.2.002403","article-title":"Automated 3-D method for the correction of axial artifacts in spectral-domain optical coherence tomography images","volume":"2","author":"Antony","year":"2011","journal-title":"Biomed Opt Express"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1109\/TPAMI.2006.19","article-title":"Optimal surface segmentation in volumetric images\u2014a graph-theoretic approach","volume":"28","author":"Li","year":"2006","journal-title":"IEEE Trans Pattern Anal Mach Intell"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1097\/IAE.0b013e3182247535","article-title":"Anatomical correlates to the bands seen in the outer retina by optical coherence tomography: literature review and model","volume":"31","author":"Spaide","year":"2011","journal-title":"Retina"},{"key":"bib17","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Ser B"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","article-title":"Statistical methods for assessing agreement between two methods of clinical measurement","volume":"1","author":"Bland","year":"1986","journal-title":"Lancet"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1177\/112067211002000221","article-title":"Optical coherence tomography findings in pseudoxanthoma elasticum","volume":"20","author":"Ari Yaylali","year":"2010","journal-title":"Eur J Ophthalmol"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"5913","DOI":"10.1167\/iovs.09-3541","article-title":"Multimodal imaging including spectral domain OCT and confocal near infrared reflectance for characterization of outer retinal pathology in pseudoxanthoma elasticum","volume":"50","author":"Charbel Issa","year":"2009","journal-title":"Investig Opthalmol Vis Sci"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/BF00409836","article-title":"Bruch's membrane in pseudoxanthoma elasticum. Histochemical, ultrastructural, and x-ray microanalytical study of the membrane and angioid streak areas","volume":"203","author":"Jensen","year":"1977","journal-title":"Albrecht Von Graefes Arch Klin Exp Ophthalmol"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1136\/bjo.2009.162644","article-title":"Added value of infrared, red-free and autofluorescence fundus imaging in pseudoxanthoma elasticum","volume":"94","author":"De Zaeytijd","year":"2010","journal-title":"Br J Ophthalmol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1016\/j.ophtha.2009.11.008","article-title":"Centrifugal fundus abnormalities in pseudoxanthoma elasticum","volume":"117","author":"Charbel Issa","year":"2010","journal-title":"Ophthalmology"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1001\/jamaophthalmol.2015.117","article-title":"Reticular pseudodrusen associated with a diseased Bruch membrane in pseudoxanthoma elasticum","volume":"133","author":"Gliem","year":"2015","journal-title":"JAMA Ophthalmol"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"6159","DOI":"10.1167\/iovs.17-22007","article-title":"Quantitative fundus autofluorescence in pseudoxanthoma elasticum","volume":"58","author":"Gliem","year":"2017","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"e0179532","DOI":"10.1371\/journal.pone.0179532","article-title":"Quantitative analysis of retinal layers on three-dimensional spectral-domain optical coherence tomography for pituitary adenoma.","volume":"12","author":"Sun","year":"2017","journal-title":"PLoS One"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"3104","DOI":"10.1167\/iovs.11-8700","article-title":"Differential optical density of subretinal spaces","volume":"53","author":"Neudorfer","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1364\/BOE.6.001632","article-title":"Impact of motion-associated noise on intrinsic optical signal imaging in humans with optical coherence tomography","volume":"6","author":"Teussink","year":"2015","journal-title":"Biomed Opt Express"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1364\/BOE.7.000022","article-title":"Retinal nerve fiber layer reflectometry must consider directional reflectance","volume":"7","author":"Huang","year":"2016","journal-title":"Biomed Opt Express"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1167\/iovs.18-24153","article-title":"Increased inner retinal layer reflectivity in eyes with acute CRVO correlates with worse visual outcomes at 12 months","volume":"59","author":"Mehta","year":"2018","journal-title":"Investig Opthalmol Vis Sci"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"16","DOI":"10.5005\/jp-journals-10078-1244","article-title":"Spectralis OCT1 versus OCT2: time efficiency and image quality of retinal nerve fiber layer thickness and Bruch's membrane opening analysis for glaucoma patients","volume":"13","author":"Bosche","year":"2019","journal-title":"J Curr Glaucoma Pract"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1364\/BOE.5.000322","article-title":"Depth-resolved model-based reconstruction of attenuation coefficients in optical coherence tomography","volume":"5","author":"Vermeer","year":"2013","journal-title":"Biomed Opt Express"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"e0148183","DOI":"10.1371\/journal.pone.0148183","article-title":"Profile and determinants of retinal optical intensity in normal eyes with spectral domain optical coherence tomography","volume":"11","author":"Chen","year":"2016","journal-title":"PLoS One"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.mam.2012.04.005","article-title":"Understanding age-related macular degeneration (AMD): relationships between the photoreceptor\/retinal pigment epithelium\/Bruch's membrane\/choriocapillaris complex","volume":"33","author":"Bhutto","year":"2012","journal-title":"Mol Aspects Med"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2009.08.003","article-title":"The dynamic nature of Bruch's membrane","volume":"29","author":"Booij","year":"2010","journal-title":"Prog Retin Eye Res"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"2800","DOI":"10.1167\/iovs.13-11613","article-title":"Relationship between the second reflective band on optical coherence tomography and multifocal electroretinography in age-related macular degeneration","volume":"54","author":"Wu","year":"2013","journal-title":"Investig Opthalmol Vis Sci"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1167\/iovs.18-25702","article-title":"Three-dimensional adaptive optics\u2014assisted visualization of photoreceptors in healthy and pathologically aged eyes","volume":"60","author":"Reumueller","year":"2019","journal-title":"Investig Opthalmol Vis Sci"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"e100080","DOI":"10.1371\/journal.pone.0100080","article-title":"Towards a quantitative OCT image analysis","volume":"9","author":"Garcia Garrido","year":"2014","journal-title":"PLoS One"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/0042-6989(73)90148-X","article-title":"The Stiles-Crawford effect-explanation and consequences","volume":"13","author":"Snyder","year":"1973","journal-title":"Vision Res"},{"key":"bib42","first-page":"1519","article-title":"A comparison of the optical Stiles-Crawford effect and retinal densitometry in a clinical setting","volume":"39","author":"DeLint","year":"1998","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"4250","DOI":"10.1167\/iovs.05-1604","article-title":"Pseudoxanthoma elasticum with generalized retinal dysfunction, a common finding?","volume":"48","author":"Audo","year":"2007","journal-title":"Investig Opthalmol Vis Sci"},{"key":"bib45","article-title":"Impaired dark adaptation associated with a diseased Bruch membrane in pseudoxanthoma elasticum [published online December 10, 2019]","author":"Hess","journal-title":"Retina"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1136\/bjo.78.1.79-a","article-title":"Dark adaptation and scotopic perimetry over \u201cpeau d'orange\u201d in pseudoxanthoma elasticum","volume":"78","author":"Holz","year":"1994","journal-title":"Br J Ophthalmol"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s40942-016-0040-0","article-title":"Automated macular choroidal thickness measurement by swept-source optical coherence tomography in pseudoxanthoma elasticum","volume":"2","author":"Dolz-Marco","year":"2016","journal-title":"Int J Retin Vitr"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/j.ajo.2011.12.013","article-title":"Macular choroidal thickness and volume in eyes with angioid streaks measured by swept source optical coherence tomography","volume":"153","author":"Ellabban","year":"2012","journal-title":"Am J Ophthalmol"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1111\/aos.2015.93.issue-4","article-title":"Optical density filters modeling media opacities cause decreased SD-OCT retinal layer thickness measurements with inter- and intra-individual variation","volume":"93","author":"Darma","year":"2015","journal-title":"Acta Ophthalmol"},{"key":"bib44","doi-asserted-by":"crossref","DOI":"10.1007\/978-94-009-9180-4_2","article-title":"Electrophysiological Studies in Groenblad-strandberg Syndrome.","volume-title":"Visual Electrodiagnosis in Systemic Diseases. Documenta Ophthalmologica Proceeding Series","author":"Fran\u00e7ois","year":"1980"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2770503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T17:41:45Z","timestamp":1723311705000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2770503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,23]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,7,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.9.8.34","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7,23]]}}}