{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:30:46Z","timestamp":1793802646572,"version":"4.6.1"},"reference-count":42,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"13","license":[{"start":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:00:00Z","timestamp":1793750400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,11,4]]},"DOI":"10.1167\/iovs.67.13.10","type":"journal-article","created":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:01:02Z","timestamp":1793800862000},"page":"10","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Retinal Layer Thickness and Hearing Performance in the UK Biobank: A Cross-Sectional Study"],"prefix":"10.1167","volume":"67","author":[{"given":"Laura A.","family":"Meliante","sequence":"first","affiliation":[{"name":"NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom"},{"name":"Department of Sense Organs, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey V.","family":"Stuart","sequence":"additional","affiliation":[{"name":"NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero G.","family":"Meliante","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mental Health and Sensory Organs (N.E.S.M.O.S.), Faculty of Medicine and Psychology, \u201cSapienza\u201d University, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dun Jack","family":"Fu","sequence":"additional","affiliation":[{"name":"NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Montesano","sequence":"additional","affiliation":[{"name":"NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N.","family":"Luben","sequence":"additional","affiliation":[{"name":"NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahantesh I.","family":"Biradar","sequence":"additional","affiliation":[{"name":"NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqi","family":"Hu","sequence":"additional","affiliation":[{"name":"NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R. P.","family":"Taylor","sequence":"additional","affiliation":[{"name":"NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Iannetta","sequence":"additional","affiliation":[{"name":"Department of Sense Organs, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Manni","sequence":"additional","affiliation":[{"name":"Department of Sense Organs, Sapienza University of Rome, Rome, Italy"},{"name":"IRCCS \u2013 Fondazione Bietti, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony P.","family":"Khawaja","sequence":"additional","affiliation":[{"name":"NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Foster","sequence":"additional","affiliation":[{"name":"NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom"},{"name":"Centre for Population Health Research and Implementation (CPHRI), SingHealth Regional Health System, Connection One, Bukit Timah Road, Singapore, Singapore"},{"name":"Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore, Singapore"},{"name":"Health Services and Systems Research, Duke\u2013NUS Medical School, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"Suppl 1","key":"bib1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000371597","article-title":"The prevalence of peripheral and central hearing impairment and its relation to cognition in older adults","volume":"19","author":"Quaranta","year":"2014","journal-title":"Audiol Neurootol"},{"issue":"suppl 1","key":"bib2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000371593","article-title":"Aging, cognitive load, dementia and hearing loss","volume":"19","author":"Martini","year":"2014","journal-title":"Audiol Neurootol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.addr.2016.01.004","article-title":"Advances in nano-based inner ear delivery systems for the treatment of sensorineural hearing loss","volume":"108","author":"Li","year":"2016","journal-title":"Adv Drug Deliv Rev"},{"issue":"10","key":"bib6","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1001\/archopht.124.10.1465","article-title":"Association between vision and hearing impairments and their combined effects on quality of life","volume":"124","author":"Chia","year":"2006","journal-title":"Arch Ophthalmol"},{"issue":"2","key":"bib7","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1001\/jamaoto.2017.2513","article-title":"Association of age-related hearing loss with cognitive function, cognitive impairment, and dementia: a systematic review and meta-analysis","volume":"144","author":"Loughrey","year":"2018","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"2","key":"bib8","first-page":"203","article-title":"Optical coherence tomography as retinal imaging biomarker of neuroinflammation\/neurodegeneration in systemic disorders in adults and children","volume":"37","author":"Vujosevic","year":"2023","journal-title":"Eye (Basingstoke)"},{"issue":"10","key":"bib9","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1001\/jamaneurol.2018.1563","article-title":"Association of retinal neurodegeneration on optical coherence tomography with dementia: a population-based study","volume":"75","author":"Mutlu","year":"2018","journal-title":"JAMA Neurol"},{"issue":"10","key":"bib10","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1001\/jamaneurol.2018.1578","article-title":"Association of retinal nerve fiber layer thinning with current and future cognitive decline: a study using optical coherence tomography","volume":"75","author":"Ko","year":"2018","journal-title":"JAMA Neurol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3389\/fnagi.2019.00069","article-title":"Retinal nerve fiber layer thinning is associated with brain atrophy: a longitudinal study in nondemented older adults","volume":"11","author":"Shi","year":"2019","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"bib12","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nrneurol.2012.227","article-title":"The retina as a window to the brain-from eye research to CNS disorders","volume":"9","author":"London","year":"2013","journal-title":"Nat Rev Neurol"},{"issue":"1","key":"bib13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41531-024-00637-x","article-title":"Association of retinal neurodegeneration with the progression of cognitive decline in Parkinson's disease","volume":"10","author":"Murueta-Goyena","year":"2024","journal-title":"NPJ Parkinsons Dis"},{"issue":"10452","key":"bib14","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission","volume":"404","author":"Livingston","year":"2024","journal-title":"Lancet"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"872967","DOI":"10.3389\/fnagi.2022.872967","article-title":"Association of visual, hearing, and dual sensory impairment with incident dementia","volume":"14","author":"Hu","year":"2022","journal-title":"Front Aging Neurosci"},{"issue":"3","key":"bib16","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1177\/13872877241304127","article-title":"The association between dual sensory impairment and dementia: a systematic review and meta-analysis","volume":"103","author":"Yoshida","year":"2025","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"bib17","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/j.1475-1313.2011.00876.x","article-title":"Association between hearing and vision impairments in older adults","volume":"32","author":"Schneck","year":"2012","journal-title":"Ophthalmic Physiol Opt"},{"issue":"2","key":"bib18","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1001\/jamaoto.2019.3987","article-title":"Association between microvascular retinal signs and age-related hearing loss in the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)","volume":"146","author":"Kim","year":"2019","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"3","key":"bib19","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1097\/AUD.0b013e3180479388","article-title":"Retinal microvascular abnormalities and age-related hearing loss: the Blue Mountains Hearing Study","volume":"28","author":"Liew","year":"2007","journal-title":"Ear Hear"},{"issue":"5","key":"bib20","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.3390\/jcm13051379","article-title":"Glaucoma, pseudoexfoliation and hearing loss: a systematic literature review","volume":"13","author":"Meliante","year":"2024","journal-title":"J Clin Med"},{"issue":"4","key":"bib21","first-page":"463","article-title":"Evaluation of retinal nerve fiber layer thickness in patients with age-related hearing loss","volume":"26","author":"Findik","year":"2019","journal-title":"Van Tip Derg"},{"issue":"4","key":"bib22","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1159\/000512004","article-title":"An evaluation of the relationship between retinal nerve fiber thickness, cochlear nerve thickness, the level of tinnitus, and hearing loss in unilateral tinnitus patients","volume":"26","author":"Avcu","year":"2021","journal-title":"Audiol Neurootol"},{"issue":"3","key":"bib23","doi-asserted-by":"publisher","first-page":"e1001779","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK Biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med"},{"issue":"2","key":"bib24","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1093\/ije\/dym276","article-title":"The UK Biobank sample handling and storage protocol for the collection, processing and archiving of human blood and urine","volume":"37","author":"Elliott","year":"2008","journal-title":"Int J Epidemiol"},{"issue":"2","key":"bib25","doi-asserted-by":"publisher","first-page":"e025077","DOI":"10.1136\/bmjopen-2018-025077","article-title":"Cohort profile: design and methods in the eye and vision consortium of UK Biobank","volume":"9","author":"Chua","year":"2019","journal-title":"BMJ Open"},{"issue":"12","key":"bib26","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1080\/14992027.2021.1902579","article-title":"The Digit Triplet Test: a scoping review","volume":"60","author":"Van den Borre","year":"2021","journal-title":"Int J Audiol"},{"issue":"1","key":"bib27","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1097\/00003446-200502000-00008","article-title":"Results from the Dutch speech-in-noise screening test by telephone","volume":"26","author":"Smits","year":"2005","journal-title":"Ear Hear"},{"issue":"1","key":"bib28","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1080\/14992020400050004","article-title":"Development and validation of an automatic speech-in-noise screening test by telephone","volume":"43","author":"Smits","year":"2004","journal-title":"Int J Audiol"},{"issue":"2","key":"bib29","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3813\/AAA.918397","article-title":"Hearcom: hearing in the communication society","volume":"97","author":"Vlaming","year":"2011","journal-title":"Acta Acustica United with Acustica"},{"issue":"10","key":"bib31","doi-asserted-by":"publisher","first-page":"e0164095","DOI":"10.1371\/journal.pone.0164095","article-title":"Optical coherence tomography in the UK Biobank Study \u2013 rapid automated analysis of retinal thickness for large population-based studies","volume":"11","author":"Keane","year":"2016","journal-title":"PLoS One"},{"issue":"20","key":"bib32","doi-asserted-by":"publisher","first-page":"21293","DOI":"10.1364\/OE.18.021293","article-title":"Automated layer segmentation of macular OCT images using dual-scale gradient information","volume":"18","author":"Yang","year":"2010","journal-title":"Optics Express"},{"issue":"12","key":"bib33","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1167\/iovs.65.12.22","article-title":"Association of ambient air pollution exposure with incident glaucoma: 12-year evidence from the UK Biobank cohort.","volume":"65","author":"Sun","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib34","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.ogla.2022.11.008","article-title":"The association of alcohol consumption with glaucoma and related traits: findings from the UK Biobank","volume":"6","author":"Stuart","year":"2023","journal-title":"Ophthalmol Glaucoma"},{"issue":"12","key":"bib35","doi-asserted-by":"publisher","first-page":"e042571","DOI":"10.1136\/bmjopen-2020-042571","article-title":"Understanding ethnic inequalities in hearing health in the UK: a cross-sectional study of the link between language proficiency and performance on the Digit Triplet Test","volume":"10","author":"Taylor","year":"2020","journal-title":"BMJ Open"},{"issue":"1","key":"bib36","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.ophtha.2019.08.015","article-title":"Comparison of associations with different macular inner retinal thickness parameters in a large cohort: the UK Biobank","volume":"127","author":"Khawaja","year":"2020","journal-title":"Ophthalmology"},{"issue":"5","key":"bib37","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.preteyeres.2012.04.004","article-title":"Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease","volume":"31","author":"Kur","year":"2012","journal-title":"Prog Retin Eye Res"},{"issue":"1-2","key":"bib38","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.heares.2011.08.006","article-title":"Physiopathology of the cochlear microcirculation","volume":"282","author":"Shi","year":"2011","journal-title":"Hear Res"},{"issue":"2","key":"bib39","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1001\/jamaoto.2015.3163","article-title":"Histopathologic evaluation of vascular findings in the cochlea in patients with presbycusis","volume":"142","author":"Kurata","year":"2016","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.brainres.2017.07.025","article-title":"Retinal metabolism: a comparative look at energetics in the retina","volume":"1672","author":"Country","year":"2017","journal-title":"Brain Res"},{"issue":"6","key":"bib41","doi-asserted-by":"publisher","first-page":"e20652","DOI":"10.1371\/journal.pone.0020652","article-title":"Fibro-vascular coupling in the control of cochlear blood flow","volume":"6","author":"Dai","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"bib42","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1093\/brain\/awaa429","article-title":"Hearing and dementia: from ears to brain","volume":"144","author":"Johnson","year":"2021","journal-title":"Brain"},{"key":"bib3","volume-title":"World report on hearing","author":"World Health Organization","year":"2021"},{"key":"bib5","first-page":"1","article-title":"Sensorineural hearing loss","volume-title":"StatPearls","author":"Tanna","year":"2023"},{"key":"bib30","volume-title":"The development of a new English sentence in noise test and an English number recognition test. MSc Dissertation","author":"Hall","year":"2006"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.13.10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:01:04Z","timestamp":1793800864000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.13.10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11,4]]},"references-count":42,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,11,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.13.10","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11,4]]}}}