{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:14:48Z","timestamp":1779196488449,"version":"3.51.4"},"reference-count":56,"publisher":"American Society for Clinical Investigation","issue":"13","funder":[{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"crossref","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH","award":["NIH 1DP2OD008752"],"award-info":[{"award-number":["NIH 1DP2OD008752"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,12]]},"abstract":"<jats:p>Numerous studies of relatively few patients have linked T cell receptor (TCR) genes to psoriasis but have yielded dramatically conflicting results. To resolve these discrepancies, we have chosen to mine RNA-Seq datasets for patterns of TCR gene segment usage in psoriasis. A meta-analysis of 3 existing and 1 unpublished datasets revealed a statistically significant link between the relative expression of TRAJ23 and psoriasis and the psoriasis-associated cytokine IL-17A. TRGV5, a TCR-\u03b3 segment, was also associated with psoriasis but correlated instead with IL-36A, other IL-36 family members, and IL-17C (not IL-17A). In contrast, TRAJ39 was strongly associated with healthy skin. T cell diversity measurements and analysis of CDR3 sequences were also conducted, revealing no psoriasis-associated public CDR3 sequences. Finally, in comparison with the expression of TCR-\u03b1\u03b2 genes, the expression of TCR-\u03b3\u03b4 genes was relatively low but mildly elevated in psoriatic skin. These results have implications for the development of targeted therapies for psoriasis and other autoimmune diseases. Also, the techniques employed in this study have applications in other fields, such as cancer immunology and infectious disease.<\/jats:p>","DOI":"10.1172\/jci.insight.120682","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T11:01:22Z","timestamp":1531306882000},"source":"Crossref","is-referenced-by-count":24,"title":["Meta-analysis of RNA sequencing datasets reveals an association between TRAJ23, psoriasis, and IL-17A"],"prefix":"10.1172","volume":"3","author":[{"given":"Alexander A.","family":"Merleev","sequence":"first","affiliation":[{"name":"Department of Dermatology, School of Medicine, UCD, Sacramento, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina I.","family":"Marusina","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine, UCD, Sacramento, California, 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