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Here, we show that 5-azacytidine, a DNA methyltransferase inhibitor, targeted to either CD4 or CD8 T cells in mice with established disease using a nanolipogel delivery system dramatically ameliorates lupus-related pathology through distinct mechanisms. In vivo targeted delivery of 5-azacytidine into CD4 T cells favors the expansion and function of Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    Tregs, whereas targeted delivery to CD8 T cells enhances the cytotoxicity and restrains the expansion of pathogenic TCR-\u03b1\u03b2\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>\u2013<\/jats:sup>\n                    CD8\n                    <jats:sup>\u2013<\/jats:sup>\n                    double-negative T cells. Our results signify the importance of cell-specific inhibition of DNA methylation in the treatment of established lupus.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.120880","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T11:01:09Z","timestamp":1534935669000},"source":"Crossref","is-referenced-by-count":50,"title":["Precision DNA demethylation ameliorates disease in lupus-prone mice"],"prefix":"10.1172","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2171-8826","authenticated-orcid":true,"given":"Hao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8072-1358","authenticated-orcid":true,"given":"Maria G.","family":"Tsokos","sequence":"additional","affiliation":[{"name":"Department of Medicine, Beth 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