{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:32:31Z","timestamp":1791772351153,"version":"4.3.4"},"reference-count":37,"publisher":"American Society for Clinical Investigation","issue":"14","funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"crossref","award":["RSG-15-061-01-TBE"],"award-info":[{"award-number":["RSG-15-061-01-TBE"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"crossref","award":["IRG-17-174-13"],"award-info":[{"award-number":["IRG-17-174-13"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute of Health","award":["T32DK007745"],"award-info":[{"award-number":["T32DK007745"]}]},{"name":"National Institute of Health","award":["5P01-HL20948"],"award-info":[{"award-number":["5P01-HL20948"]}]},{"name":"National Institute of Health","award":["P30CA142543"],"award-info":[{"award-number":["P30CA142543"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,26]]},"abstract":"<jats:p>\n                    Cachexia syndrome consists of adipose and muscle loss, often despite normal food intake. We hypothesized that cachexia-associated adipose wasting is driven in part by tumor humoral factors that induce adipocyte lipolysis. We developed an assay to purify secreted factors from a cachexia-inducing colon cancer line that increases lipolysis in adipocytes and identified leukemia inhibitory factor (LIF) by mass spectrometry. Recombinant LIF induced lipolysis in vitro. Peripheral LIF administered to mice caused &gt;50% loss of adipose tissue and &gt;10% reduction in body weight despite only transient hypophagia due to decreasing leptin. LIF-injected mice lacking leptin (\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    ) resulted in persistent hypophagia and loss of adipose tissue and body weight. LIF\u2019s peripheral role of initiating lipolysis in adipose loss was confirmed in pair-fed\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    mouse studies. Our studies demonstrate that (a) LIF is a tumor-secreted factor that promotes cachexia-like adipose loss when administered peripherally, (b) LIF directly induces adipocyte lipolysis, (c) LIF has the ability to sustain adipose and body weight loss through an equal combination of peripheral and central contributions, and (d) LIF\u2019s central effect is counterbalanced by decreased leptin signaling, providing insight into cachexia\u2019s wasting, despite normophagia.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.121221","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T11:01:04Z","timestamp":1532516464000},"source":"Crossref","is-referenced-by-count":84,"title":["Cachexia-associated adipose loss induced by tumor-secreted leukemia inhibitory factor is counterbalanced by decreased leptin"],"prefix":"10.1172","volume":"3","author":[{"given":"Gurpreet K.","family":"Arora","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics,"},{"name":"Department of Radiation Oncology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriram","family":"Narayanan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneeth","family":"Iyengar","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology,"},{"name":"Harold C. 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