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Based on a comparison of this reference genome with 36 other sequenced mouse strains, we generated an overview of all protein-coding genes that are deviant in this reference genome, compared with consensus protein-coding mouse gene sequences. We provide PROVEAN scores, reflecting the likelihood that these C57BL\/6J proteins have lost function. We thus identified numerous abnormal proteins, and biological pathways, specifically present in C57BL\/6J, suggesting the important caveats of this reference mouse strain, and linking candidate genes to some of the best-known phenotypes of this strain.<\/jats:p>","DOI":"10.1172\/jci.insight.121758","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T11:01:22Z","timestamp":1531306882000},"source":"Crossref","is-referenced-by-count":10,"title":["Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL\/6J"],"prefix":"10.1172","volume":"3","author":[{"given":"Steven","family":"Timmermans","sequence":"first","affiliation":[{"name":"VIB Center for Inflammation Research, Ghent, Belgium."},{"name":"Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Libert","sequence":"additional","affiliation":[{"name":"VIB 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