{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:26:43Z","timestamp":1788830803953,"version":"build-2803163510"},"reference-count":65,"publisher":"American Society for Clinical Investigation","issue":"19","funder":[{"name":"NIH","award":["R01AR056016,R21AR061881,P30AR069632,K01 AR068475,K08 AR069111,S10OD020056"],"award-info":[{"award-number":["R01AR056016,R21AR061881,P30AR069632,K01 AR068475,K08 AR069111,S10OD020056"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,4]]},"abstract":"<jats:p>\n                    Alopecia areata (AA) is an autoimmune disease in which cytotoxic T cells specifically target growing hair follicles. We used high-throughput TCR sequencing in the C3H\/HeJ mouse model of AA and in human AA patients to gain insight into pathogenic T cell populations and their dynamics, which revealed clonal CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell expansions in lesional skin. In the C3H\/HeJ model, we observed interindividual sharing of TCR\u03b2 chain protein sequences, which strongly supports a model of antigenic drive in AA. The overlap between the lesional TCR repertoire and a population of CD8\n                    <jats:sup>+<\/jats:sup>\n                    NKG2D\n                    <jats:sup>+<\/jats:sup>\n                    T cells in skin-draining lymph nodes identified this subset as pathogenic effectors. In AA patients, treatment with the oral JAK inhibitor tofacitinib resulted in a decrease in clonally expanded CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in the scalp but also revealed that many expanded lesional T cell clones do not completely disappear from either skin or blood during treatment with tofacitinib, which may explain in part the relapse of disease after stopping treatment.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.121949","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T11:01:24Z","timestamp":1538564484000},"source":"Crossref","is-referenced-by-count":60,"title":["High-throughput T cell receptor sequencing identifies clonally expanded CD8+ T cell populations in alopecia areata"],"prefix":"10.1172","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6707-6585","authenticated-orcid":true,"given":"Annemieke","family":"de 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