{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:44:25Z","timestamp":1791499465915,"version":"4.3.4"},"reference-count":49,"publisher":"American Society for Clinical Investigation","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,18]]},"abstract":"<jats:p>\n                    Multiple reports of uncoupling protein 1 (\n                    <jats:italic>UCP1<\/jats:italic>\n                    ) expression have established its presence in human epicardial adipose tissue (eAT). Its functional relevance to eAT, however, remains largely unknown. In a recent study, we reported that adrenergic stimulation of eAT was associated with downregulation of secreted proteins involved in oxidative stress\u2013related and immune-related pathways. Here, we explored the\n                    <jats:italic>UCP1<\/jats:italic>\n                    -associated features of human eAT using next-generation deep sequencing. Paired biopsies of eAT, mediastinal adipose tissue (mAT), and subcutaneous adipose tissue (sAT) obtained from cardiac surgery patients, with specific criteria of high and low expression of\n                    <jats:italic>UCP1<\/jats:italic>\n                    in eAT, were subjected to RNA sequencing. Although eAT exhibited a depot-specific upregulation in the immune-related pathways relative to mAT and sAT, high\n                    <jats:italic>UCP1<\/jats:italic>\n                    expression in eAT was specifically associated with differential gene expression that functionally corresponded with downregulation in the production of reactive oxygen species and immune responses, including T cell homeostasis. Our data indicate that\n                    <jats:italic>UCP1<\/jats:italic>\n                    and adaptive immunity share a reciprocal relationship at the whole-transcriptome level, thereby supporting a plausible role for\n                    <jats:italic>UCP1<\/jats:italic>\n                    in maintaining tissue homeostasis in human eAT.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.123618","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T11:09:08Z","timestamp":1555499348000},"source":"Crossref","is-referenced-by-count":47,"title":["UCP1 expression\u2013associated gene signatures of human epicardial adipose tissue"],"prefix":"10.1172","volume":"4","author":[{"given":"Kanta","family":"Chechi","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada."},{"name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec (IUCPQ), Chemin Sainte-Foy, Qu\u00e9bec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7311-475X","authenticated-orcid":true,"given":"Jinchu","family":"Vijay","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, McGill University, and Genome Qu\u00e9bec Innovation Centre, Montreal, Qu\u00e9bec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Voisine","sequence":"additional","affiliation":[{"name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec (IUCPQ), Chemin Sainte-Foy, Qu\u00e9bec, Canada."},{"name":"Department of Cardiovascular Surgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec (IUCPQ), Chemin Sainte-Foy, Qu\u00e9bec, Canada."},{"name":"Laboratory of Cardiovascular Pathobiology, Department of Surgery, Faculty of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3067-3711","authenticated-orcid":true,"given":"Yohan","family":"Boss\u00e9","sequence":"additional","affiliation":[{"name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec (IUCPQ), Chemin Sainte-Foy, Qu\u00e9bec, Canada."},{"name":"Department of Molecular Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Tchernof","sequence":"additional","affiliation":[{"name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec (IUCPQ), Chemin Sainte-Foy, Qu\u00e9bec, Canada."},{"name":"School of Nutrition, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, 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