{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:17:45Z","timestamp":1791505065389,"version":"4.3.4"},"reference-count":28,"publisher":"American Society for Clinical Investigation","issue":"21","funder":[{"name":"National Institute of Health","award":["CA200422,CA180779,DE023926,AI073099,AI116585,AI129496,AI140705,AI069120,AI056154,AI078389,AI28697,AI40718,AI129534-01"],"award-info":[{"award-number":["CA200422,CA180779,DE023926,AI073099,AI116585,AI129496,AI140705,AI069120,AI056154,AI078389,AI28697,AI40718,AI129534-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,2]]},"abstract":"<jats:p>\n                    <jats:bold>BACKGROUND.<\/jats:bold>\n                    An intricate fetal-maternal immune crosstalk during pregnancy is essential for a healthy birth. Hence, the infection-induced alterations of maternal immunity often lead to adverse outcomes for mother and\/or child. The emergence of Zika virus (ZIKV) infection in pregnant women has been associated with more than 3,000 cases of microcephaly and nervous system malformations.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>METHODS.<\/jats:bold>\n                    To explore the potential correlation of ZIKV-induced alteration of maternal immunity with fetal abnormalities, we performed extensive sera immunoprofiling of 74 pregnant women: 30 symptomatic ZIKV\n                    <jats:sup>\n                      <jats:sup>+<\/jats:sup>\n                    <\/jats:sup>\n                    pregnant patients and 30 healthy pregnant controls in ZIKV-endemic Rio de Janeiro, along with 14 healthy pregnant controls in non-endemic Los Angeles.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS.<\/jats:bold>\n                    Extensive multiplexing analysis of 69 cytokines revealed that CXCL10, CCL2, and CCL8 chemokines were specifically associated with symptomatic ZIKV\n                    <jats:sup>\n                      <jats:sup>+<\/jats:sup>\n                    <\/jats:sup>\n                    infection during pregnancy, and distinct immunoprofiles were detected at different trimesters in ZIKV-infected pregnant women. Intriguingly, the high CCL2 level and its inverse correlation with CD163, TNFRSF1A, and CCL22 levels was apparently associated with ZIKV-induced abnormal birth.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>CONCLUSION.<\/jats:bold>\n                    Our findings provide insights into the alteration of ZIKV-elicited maternal immunity, serving as a potential clinical biomarker platform.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>FUNDING.<\/jats:bold>\n                    NIH (CA200422, CA180779, DE023926, AI073099, AI116585, AI129496, AI140705, AI069120, AI056154, AI078389, AI28697, AI40718 and AI129534-01), Hastings Foundation, Fletcher Jones Foundation, Departamento de Ci\u00eancia e Tecnologia (DECIT\/25000.072811\/2016-17) do Minist\u00e9rio da Sa\u00fade do Brasil, and Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de Nivel Superior CAPES\/88887.116627\/2016-01.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.124152","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T11:01:23Z","timestamp":1541070083000},"source":"Crossref","is-referenced-by-count":38,"title":["Biomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnancies"],"prefix":"10.1172","volume":"3","author":[{"given":"Suan-Sin","family":"Foo","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology and Immunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8840-1823","authenticated-orcid":true,"given":"Weiqiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Zilkha Neurogenetic Institute, Los Angeles, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai-Suet","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology and"},{"name":"Institute for Glycomics, Griffith University, Gold Coast, Southport, Queensland, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Ae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genhong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Genetics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Nielsen-Saines","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, David Geffen School of Medicine, UCLA, Marion Davies Children\u2019s Health Center, Los Angeles, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Brasil","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa Cl\u00ednica em Doen\u00e7as Febris Agudas, Instituto Nacional de Infectologia Evandro Chagas, Fonda\u00e7\u00e3o Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae U.","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2018,11,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760150192"},{"key":"B2","unstructured":"PAHO and WHO. Zika suspected and confirmed cases reported by countries and territories in the Americas Cumulative cases, 2015\u20132017. PAHO website. https:\/\/www.paho.org\/hq\/dmdocuments\/2017\/2017-oct-5-phe-ZIKV-cases.pdf Updated October 5, 2017. Accessed October 11, 2018."},{"key":"B3","unstructured":"CDC. Outcomes of Pregnancies with Laboratory Evidence of Possible Zika Virus Infection, 2015\u20132018. CDC website. https:\/\/www.cdc.gov\/pregnancy\/zika\/data\/pregnancy-outcomes.html Updated March 27, 2018. Accessed October 11, 2018"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6623e1"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6613e1"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602412"},{"key":"B7"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1405047"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.479"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/24.3.334"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004636"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12289"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-017-0016-3"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805715"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00562-6"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2017.02.007"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2012.10.007"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056045"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1172\/JCI81227"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1209788"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2406"},{"key":"B22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2014.00298","article-title":"Monocytes and macrophages in pregnancy and pre-eclampsia","volume":"5","author":"Faas","year":"2014","journal-title":"Front Immunol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.117681"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3201\/eid1408.080287"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1605367"},{"issue":"2","key":"B26","doi-asserted-by":"crossref","DOI":"10.5041\/RMMJ.10305","article-title":"Maternal inflammation, fetal brain implications and suggested neuroprotection: a summary of 10 years of research in animal models","volume":"8","author":"Ginsberg","year":"2017","journal-title":"Rambam Maimonides Med J"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix261"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix472"}],"container-title":["JCI Insight"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/insight.jci.org\/articles\/view\/124152\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:39:38Z","timestamp":1779194378000},"score":1,"resource":{"primary":{"URL":"https:\/\/insight.jci.org\/articles\/view\/124152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,2]]},"references-count":28,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2018,11,2]]},"published-print":{"date-parts":[[2018,11,2]]}},"alternative-id":["10.1172\/jci.insight.124152"],"URL":"https:\/\/doi.org\/10.1172\/jci.insight.124152","relation":{},"ISSN":["2379-3708"],"issn-type":[{"value":"2379-3708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,2]]},"article-number":"e124152"}}