{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:04:33Z","timestamp":1789758273064,"version":"4.0.1"},"reference-count":69,"publisher":"American Society for Clinical Investigation","issue":"11","funder":[{"name":"NIH","award":["training grant T32-GM007288 to A. Stock from the NIH"],"award-info":[{"award-number":["training grant T32-GM007288 to A. Stock from the NIH"]}]},{"DOI":"10.13039\/100000069","name":"NIAMS","doi-asserted-by":"crossref","award":["(AR065594) to C. Putterman."],"award-info":[{"award-number":["(AR065594) to C. Putterman."]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,6]]},"abstract":"<jats:p>\n                    The central nervous system manifestations of systemic lupus erythematosus (SLE) remain poorly understood. Given the well-defined role of autoantibodies in other lupus manifestations, extensive work has gone into the identification of neuropathic autoantibodies. However, attempts to translate these findings to patients with SLE have yielded mixed results. We used the MRL\/MpJ-\n                    <jats:italic>Fas<\/jats:italic>\n                    <jats:sup>lpr\/lpr<\/jats:sup>\n                    mouse, a well-established, spontaneous model of SLE, to establish the immune effectors responsible for brain disease. Transcriptomic analysis of the MRL\/MpJ-\n                    <jats:italic>Fas<\/jats:italic>\n                    <jats:sup>lpr\/lpr<\/jats:sup>\n                    choroid plexus revealed an expression signature driving tertiary lymphoid structure formation, including chemokines related to stromal reorganization and lymphocyte compartmentalization. Additionally, transcriptional profiles indicated various stages of lymphocyte activation and germinal center formation. The extensive choroid plexus infiltrate present in MRL\/MpJ-\n                    <jats:italic>Fas<\/jats:italic>\n                    <jats:sup>lpr\/lpr<\/jats:sup>\n                    mice with overt neurobehavioral deficits included locally proliferating B and T cells, intercellular interactions between lymphocytes and antigen-presenting cells, as well as evidence for in situ somatic hypermutation and class switch recombination. Furthermore, the choroid plexus was a site for trafficking lymphocytes into the brain. Finally, histological evaluation in human lupus patients with neuropsychiatric manifestations revealed increased leukocyte migration through the choroid plexus. These studies identify a potential new pathway underlying neuropsychiatric lupus and support tertiary lymphoid structure formation in the choroid plexus as a novel mechanism of brain-immune interfacing.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.124203","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T11:01:16Z","timestamp":1559732476000},"source":"Crossref","is-referenced-by-count":62,"title":["Tertiary lymphoid structures in the choroid plexus in neuropsychiatric lupus"],"prefix":"10.1172","volume":"4","author":[{"given":"Ariel D.","family":"Stock","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Der","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5907-3269","authenticated-orcid":true,"given":"Sivan","family":"Gelb","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology and Cancer Research, Faculty of Medicine, The Hebrew University, Ein-Kerem, Jerusalem, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Weidenheim","sequence":"additional","affiliation":[{"name":"Division of Neuropathology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayal","family":"Ben-Zvi","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology and Cancer Research, Faculty of Medicine, The Hebrew University, Ein-Kerem, Jerusalem, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3204-6068","authenticated-orcid":true,"given":"Chaim","family":"Putterman","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York, USA."},{"name":"Division of Rheumatology, Albert Einstein College of Medicine, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2019,6,6]]},"reference":[{"key":"B1"},{"issue":"1","key":"B2","first-page":"34","article-title":"Antiribosomal P protein antibodies in cerebrospinal fluid are associated with neuropsychiatric systemic lupus erythematosus","volume":"32","author":"Yoshio","year":"2005","journal-title":"J Rheumatol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1177\/0961203307078224"},{"key":"B4","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-015-0423-4","article-title":"Neuropsychiatric systemic lupus erythematosus persists despite attenuation of systemic disease in MRL\/lpr mice","volume":"12","author":"Stock","year":"2015","journal-title":"J Neuroinflammation"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.08.015"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/0889-1591(92)90048-S"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2008.11.009"},{"issue":"2","key":"B8","first-page":"183","article-title":"Depression as an initial feature of systemic lupus erythematosus? 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