{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:13:34Z","timestamp":1792113214926,"version":"4.4.0"},"reference-count":41,"publisher":"American Society for Clinical Investigation","issue":"1","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 AR063962"],"award-info":[{"award-number":["R01 AR063962"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 CA203721"],"award-info":[{"award-number":["R01 CA203721"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"KL2\/Catalyst Medical Research Investigator Training (CMeRIT) program","award":["KL2"],"award-info":[{"award-number":["KL2"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 CA122569"],"award-info":[{"award-number":["R01 CA122569"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,10]]},"abstract":"<jats:p>\n                    Psoralen plus UVA (PUVA) is an effective therapy for mycosis fungoides (MF), the skin-limited variant of cutaneous T cell lymphoma (CTCL). In low-burden patients, PUVA reduced or eradicated malignant T cells and induced clonal expansion of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells associated with malignant T cell depletion. High-burden patients appeared to clinically improve but large numbers of malignant T cells persisted in skin. Clinical improvement was linked to turnover of benign T cell clones but not to malignant T cell reduction. Benign T cells were associated with the Th2-recruiting chemokine CCL18 before therapy and with the Th1-recruiting chemokines CXCL9, CXCL10, and CXCL11 after therapy, suggesting a switch from Th2 to Th1. Inflammation was correlated with OX40L and CD40L gene expression; immunostaining localized these receptors to CCL18-expressing c-Kit\n                    <jats:sup>+<\/jats:sup>\n                    dendritic cells that clustered together with CD40\n                    <jats:sup>+<\/jats:sup>\n                    OX40\n                    <jats:sup>+<\/jats:sup>\n                    benign and CD40\n                    <jats:sup>+<\/jats:sup>\n                    CD40L\n                    <jats:sup>+<\/jats:sup>\n                    malignant T cells, creating a proinflammatory synapse in skin. Our data suggest that visible inflammation in CTCL results from the recruitment and activation of benign T cells by c-Kit\n                    <jats:sup>+<\/jats:sup>\n                    OX40L\n                    <jats:sup>+<\/jats:sup>\n                    CD40L\n                    <jats:sup>+<\/jats:sup>\n                    dendritic cells and that this activation may provide tumorigenic signals. Targeting c-Kit, OX40, and CD40 signaling may be novel therapeutic avenues for the treatment of MF.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.124233","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T09:16:22Z","timestamp":1547111782000},"source":"Crossref","is-referenced-by-count":59,"title":["Benign T cells drive clinical skin inflammation in cutaneous T cell lymphoma"],"prefix":"10.1172","volume":"4","author":[{"given":"Pablo","family":"Vieyra-Garcia","sequence":"first","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA."},{"name":"Research Unit for Photodermatology, Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack D.","family":"Crouch","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"O\u2019Malley","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward W.","family":"Seger","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao H.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica E.","family":"Teague","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Vromans","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Gehad","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thet Su","family":"Win","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zizi","family":"Yu","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth L.","family":"Lowry","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5717-2490","authenticated-orcid":true,"given":"Jung-Im","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA."},{"name":"Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain H.","family":"Rook","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wolf","sequence":"additional","affiliation":[{"name":"Research Unit for Photodermatology, Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael A.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2019,1,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-11-251926"},{"issue":"117","key":"B3","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003008","article-title":"Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients","volume":"4","author":"Clark","year":"2012","journal-title":"Sci Transl Med"},{"issue":"7","key":"B4","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1001\/archderm.139.7.857","article-title":"Long-term outcome of 525 patients with mycosis fungoides and Sezary syndrome: clinical prognostic factors and risk for disease progression","volume":"139","author":"Kim","year":"2003","journal-title":"Arch Dermatol"},{"issue":"5 Pt 1","key":"B5","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0190-9622(94)70240-3","article-title":"Photochemotherapy beyond psoriasis","volume":"31","author":"Honig","year":"1994","journal-title":"J Am Acad Dermatol"},{"issue":"1\u20132","key":"B6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/1011-1344(92)85080-E","article-title":"The evolution of photochemotherapy with psoralens and UVA (PUVA): 2000 BC to 1992 AD","volume":"14","author":"Pathak","year":"1992","journal-title":"J Photochem Photobiol B, Biol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.09.033"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.3.305"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.89.8.1240"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.116342"},{"issue":"6","key":"B11","first-page":"1447","article-title":"Discordant expression of antigens between intraepidermal and intradermal T cells in mycosis fungoides","volume":"137","author":"Michie","year":"1990","journal-title":"Am J Pathol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.05.040"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04495.x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/nm1766"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-02-630335"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v29.i3.10"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa9122"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1996.tb00921.x"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.2.671"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.9.4465"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-01-070748"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199905)29:05<1610::AID-IMMU1610>3.0.CO;2-8"},{"issue":"2","key":"B23","first-page":"452","article-title":"Coexpression of CD40 and CD40 ligand in cutaneous T-cell lymphoma (mycosis fungoides)","volume":"61","author":"Storz","year":"2001","journal-title":"Cancer Res"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04994.x"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.06.082"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1220"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21102"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v27.i5.20"},{"issue":"1","key":"B29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1365-2133.1995.tb02485.x","article-title":"Cutaneous colonization with staphylococci influences the disease activity of S\u00e9zary syndrome: a potential role for bacterial superantigens","volume":"133","author":"Tokura","year":"1995","journal-title":"Br J Dermatol"},{"issue":"1","key":"B30","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1182\/blood.V89.1.32.32_32_40","article-title":"Association of erythrodermic cutaneous T-cell lymphoma, superantigen-positive Staphylococcus aureus, and oligoclonal T-cell receptor V beta gene expansion","volume":"89","author":"Jackow","year":"1997","journal-title":"Blood"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-017863"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3390\/toxins5081402"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1054\/blre.2001.0155"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-11-256040"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000157278.02848.C7"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404182"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404913"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.4.2506"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00969.x"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08504.x"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3444"}],"container-title":["JCI Insight"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/insight.jci.org\/articles\/view\/124233\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:35:59Z","timestamp":1779194159000},"score":1,"resource":{"primary":{"URL":"http:\/\/insight.jci.org\/articles\/view\/124233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,10]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,10]]},"published-print":{"date-parts":[[2019,1,10]]}},"alternative-id":["10.1172\/jci.insight.124233"],"URL":"https:\/\/doi.org\/10.1172\/jci.insight.124233","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.736561170.793573957","asserted-by":"object"}]},"ISSN":["2379-3708"],"issn-type":[{"value":"2379-3708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,10]]},"article-number":"e124233"}}