{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:29:11Z","timestamp":1793244551822,"version":"4.5.0"},"reference-count":38,"publisher":"American Society for Clinical Investigation","issue":"5","funder":[{"name":"National Institute of Health","award":["NIH grants R21AI103839 (to GYL)"],"award-info":[{"award-number":["NIH grants R21AI103839 (to GYL)"]}]},{"name":"National Institute of Health","award":["R01GM099530 (to HL)."],"award-info":[{"award-number":["R01GM099530 (to HL)."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,7]]},"abstract":"<jats:p>\n                    Genomic studies revealed the existence of health- and acne-associated\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>acnes<\/jats:italic>\n                    strains and suggested novel approaches for broadening understanding of acne vulgaris. However, clinical association of\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>acnes<\/jats:italic>\n                    with disease or health has yet to be corroborated experimentally. Current animal models of acne do not closely mimic human disease and have unclear translational value. We have developed a murine model of acne by combining\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>acnes<\/jats:italic>\n                    inoculation with topical application of a synthetic human sebum. We showed that human sebum promoted persistence of intradermally injected\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>acnes<\/jats:italic>\n                    with little loss of viability after 1 week and permitted use of more physiologic inoculums. Application of acne-associated\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>acnes<\/jats:italic>\n                    RT4\/5 strains led to development of moderate to severe skin pathology compared with application of health-associated type II\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>acnes<\/jats:italic>\n                    strains (RT2\/6). RT4\/5\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>acnes<\/jats:italic>\n                    strains uniformly induced higher levels of KC (IL-8), IL-1\u03b1, IL-1\u03b2, and IL-6 in vitro and in vivo compared with type II\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>acnes<\/jats:italic>\n                    strains. Overall, our data provide immunopathologic corroboration of health and disease association of clinical\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>acnes<\/jats:italic>\n                    strains and inform on a platform to query putative virulence factors uncovered by genomic studies.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.124687","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T11:02:59Z","timestamp":1551870179000},"source":"Crossref","is-referenced-by-count":59,"title":["Propionibacterium acnes\u2013induced immunopathology correlates with health and disease association"],"prefix":"10.1172","volume":"4","author":[{"given":"Stacey L.","family":"Kolar","sequence":"first","affiliation":[{"name":"Division of Pediatric Infectious Diseases and Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Ming","family":"Tsai","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases and Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA."},{"name":"Division of Infectious Diseases, Department of Pediatrics, UCSD, San Diego, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Torres","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases and Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemo","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, 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