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How podocytes maintain such a high level of autophagy, however, remains unclear. Here we report that signal regulatory protein \u03b1 (SIRP\u03b1) plays a key role in promoting podocyte autophagy. Unlike other glomerular cells, podocytes strongly expressed SIRP\u03b1, which was, however, downregulated in patients with focal segmental glomerulosclerosis and mice with experimental nephropathy. Podocyte SIRP\u03b1 levels were inversely correlated with the severity of podocyte injury and proteinuria but positively with autophagy. Compared with WT littermates,\n                    <jats:italic>Sirpa<\/jats:italic>\n                    -deficient mice displayed greater age-related podocyte injury and proteinuria and developed more rapid and severe renal injury in various models of experimental nephropathy. Mechanistically, podocyte SIRP\u03b1 strongly reduced Akt\/GSK-3\u03b2\/\u03b2-catenin signaling, leading to an increase in autophagic activity. Our findings thus demonstrate a critical protective role of SIRP\u03b1 in podocyte survival via maintenance of autophagic activity.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.124747","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T12:07:03Z","timestamp":1552997223000},"source":"Crossref","is-referenced-by-count":17,"title":["Signal regulatory protein \u03b1 protects podocytes through promotion of autophagic activity"],"prefix":"10.1172","volume":"4","author":[{"given":"Limin","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, Nanjing University School of Life Sciences, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research 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