{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:50:23Z","timestamp":1792497023444,"version":"4.5.0"},"reference-count":42,"publisher":"American Society for Clinical Investigation","issue":"17","license":[{"start":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"crossref","award":["PG\/11\/80\/29135,PG\/16\/31\/32130,PG\/13\/55\/30365"],"award-info":[{"award-number":["PG\/11\/80\/29135,PG\/16\/31\/32130,PG\/13\/55\/30365"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,5]]},"abstract":"<jats:p>\n                    It has been hypothesized that IL-1\u03b1 is released from damaged cardiomyocytes following myocardial infarction (MI) and activates cardiac fibroblasts via its receptor (IL-1R1) to drive the early stages of cardiac remodeling. This study aimed to definitively test this hypothesis using cell type\u2013specific IL-1\u03b1 and IL-1R1\u2013KO mouse models. A floxed\n                    <jats:italic>Il1a<\/jats:italic>\n                    mouse was created and used to generate a cardiomyocyte-specific IL-1\u03b1\u2013KO (MIL1AKO) mouse line. A tamoxifen-inducible fibroblast-specific IL-1R1 hemizygous KO (FIL1R1KO) mouse line was also generated. Mice underwent experimental MI (permanent left anterior descending coronary artery ligation), and cardiac function was determined 4 weeks later by conductance pressure-volume catheter analysis. Molecular markers of remodeling were evaluated at various time points by real-time RT-PCR and histology. MIL1AKO mice showed no difference in cardiac function or molecular markers of remodeling after MI compared with littermate controls. In contrast, FIL1R1KO mice showed improved cardiac function and reduced remodeling markers after MI compared with littermate controls. In conclusion, these data highlight a key role for the IL-1R1\/cardiac fibroblast signaling axis in regulating remodeling after MI and provide support for the continued development of anti\u2013IL-1 therapies for improving cardiac function after MI. Cardiomyocyte-derived IL-1\u03b1 was not an important contributor to remodeling after MI in this model.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.125074","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T12:01:26Z","timestamp":1565265686000},"source":"Crossref","is-referenced-by-count":69,"title":["Fibroblast-specific deletion of IL-1 receptor-1 reduces adverse cardiac remodeling following myocardial infarction"],"prefix":"10.1172","volume":"4","author":[{"given":"Sumia A.","family":"Bageghni","sequence":"first","affiliation":[{"name":"Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4967-6314","authenticated-orcid":true,"given":"Karen E.","family":"Hemmings","sequence":"additional","affiliation":[{"name":"Discovery and 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