{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:10:58Z","timestamp":1779196258769,"version":"3.51.4"},"reference-count":51,"publisher":"American Society for Clinical Investigation","issue":"9","funder":[{"DOI":"10.13039\/100000057","name":"NIGMS","doi-asserted-by":"crossref","award":["GM113228,GM104323,"],"award-info":[{"award-number":["GM113228,GM104323,"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000057","name":"NIGMS","doi-asserted-by":"crossref","award":["GM109779"],"award-info":[{"award-number":["GM109779"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"crossref","award":["AI104699"],"award-info":[{"award-number":["AI104699"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,2]]},"abstract":"<jats:p>\n                    Recent seminal studies have revealed that laboratory mice differ from adult humans with regard to the frequency, number, and distribution of memory T cells. Because our data show that memory T cells are more susceptible to sepsis-induced death than naive T cells, in this study we developed a model in which mice possess a memory T cell compartment more similar to that of adult humans, to better study immune responses during sepsis in the more physiologically relevant context of high frequencies of memory T cells. Using this model, we found that CD44\n                    <jats:sup>hi<\/jats:sup>\n                    memory T cells significantly upregulated the coinhibitory molecule 2B4 during sepsis, and 2B4\n                    <jats:sup>+<\/jats:sup>\n                    memory T cells coexpressed markers of both activation and exhaustion. Genetic deficiency in 2B4 resulted in decreased mortality during sepsis. Mechanistically, this decreased mortality was associated with reduced caspase-3\/7\n                    <jats:sup>+<\/jats:sup>\n                    apoptotic T cells in 2B4\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    relative to WT, septic hosts. These results were corroborated by analysis of PBMCs isolated from human patients with sepsis, which showed increased frequencies of caspase-3\/7\n                    <jats:sup>+<\/jats:sup>\n                    apoptotic cells among 2B4\n                    <jats:sup>+<\/jats:sup>\n                    relative to 2B4\n                    <jats:sup>\u2013<\/jats:sup>\n                    T cells. Thus, 2B4 plays a critical role in sepsis-induced apoptosis in both murine memory T cells and those isolated from human patients with sepsis.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.126030","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T11:01:25Z","timestamp":1556708485000},"source":"Crossref","is-referenced-by-count":17,"title":["Increased attrition of memory T cells during sepsis requires 2B4"],"prefix":"10.1172","volume":"4","author":[{"given":"Jianfeng","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Surgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Surgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yini","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Surgery, 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