{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:23:50Z","timestamp":1785306230314,"version":"3.55.0"},"reference-count":72,"publisher":"American Society for Clinical Investigation","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,21]]},"abstract":"<jats:p>\n                    Antibodies and cytotoxic T cells represent 2 arms of host defense against pathogens. We hypothesized that vaccines that induce both high-magnitude CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell responses and antibody responses might confer enhanced protection against HIV. To test this hypothesis, we immunized 3 groups of nonhuman primates: (a) Group 1, which includes sequential immunization regimen involving heterologous viral vectors (HVVs) comprising vesicular stomatitis virus, vaccinia virus, and adenovirus serotype 5\u2013expressing SIVmac239 Gag; (b) Group 2, which includes immunization with a clade C HIV-1 envelope (Env) gp140 protein adjuvanted with nanoparticles containing a TLR7\/8 agonist (3M-052); and (c) Group 3, which includes a combination of both regimens. Immunization with HVVs induced very high\u2013magnitude Gag-specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell responses in blood and tissue-resident CD8\n                    <jats:sup>+<\/jats:sup>\n                    memory T cells in vaginal mucosa. Immunization with 3M-052 adjuvanted Env protein induced robust and persistent antibody responses and long-lasting innate responses. Despite similar antibody titers in Groups 2 and 3, there was enhanced protection in the younger animals in Group 3, against intravaginal infection with a heterologous SHIV strain. This protection correlated with the magnitude of the serum and vaginal Env-specific antibody titers on the day of challenge. Thus, vaccination strategies that induce both CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell and antibody responses can confer enhanced protection against infection.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.126047","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T11:01:38Z","timestamp":1550660498000},"source":"Crossref","is-referenced-by-count":65,"title":["Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques"],"prefix":"10.1172","volume":"4","author":[{"given":"Caroline","family":"Petitdemange","sequence":"first","affiliation":[{"name":"Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhir Pai","family":"Kasturi","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9906-6234","authenticated-orcid":true,"given":"Pamela A.","family":"Kozlowski","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafiq","family":"Nabi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare F.","family":"Quarnstrom","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep Babu Jagadeesh","family":"Reddy","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia A.","family":"Derdeyn","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Emory Vaccine Center, and Yerkes National Primate Research Center."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori M.","family":"Spicer","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Emory Vaccine Center, and Yerkes National Primate Research Center."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parin","family":"Patel","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Traci","family":"Legere","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yevgeniy O.","family":"Kovalenkov","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center, School of Medicine, Emory University, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6653-6655","authenticated-orcid":true,"given":"Celia C.","family":"Labranche","sequence":"additional","affiliation":[{"name":"Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Villinger","sequence":"additional","affiliation":[{"name":"New Iberia Research Center, University of Louisiana Lafayette, Lafayette, Louisiana, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Tomai","sequence":"additional","affiliation":[{"name":"3M Drug Delivery Systems, Saint Paul, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Vasilakos","sequence":"additional","affiliation":[{"name":"3M Drug Delivery Systems, Saint Paul, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barton","family":"Haynes","sequence":"additional","affiliation":[{"name":"Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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