{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:56:41Z","timestamp":1787061401068,"version":"build-2736575974"},"reference-count":53,"publisher":"American Society for Clinical Investigation","issue":"22","license":[{"start":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T00:00:00Z","timestamp":1573689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"crossref","award":["PG\/15\/93\/31834"],"award-info":[{"award-number":["PG\/15\/93\/31834"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,14]]},"abstract":"<jats:p>\n                    Cardiomyopathies are complex heart muscle diseases that can be inherited or acquired. Dilated cardiomyopathy can result from mutations in\n                    <jats:italic>LMNA,<\/jats:italic>\n                    encoding the nuclear intermediate filament proteins lamin A\/C. Some\n                    <jats:italic>LMNA<\/jats:italic>\n                    mutations lead to accumulation of the lamin A precursor, prelamin A, which is disease causing in a number of tissues, yet its impact upon the heart is unknown. Here, we discovered myocardial prelamin A accumulation occurred in a case of dilated cardiomyopathy, and we show that a potentially novel mouse model of cardiac-specific prelamin A accumulation exhibited a phenotype consistent with inflammatory cardiomyopathy, which we observed to be similar to HIV-associated cardiomyopathy, an acquired disease state. Numerous HIV protease therapies are known to inhibit ZMPSTE24, the enzyme responsible for prelamin A processing, and we confirmed that accumulation of prelamin A occurred in HIV\n                    <jats:sup>+<\/jats:sup>\n                    patient cardiac biopsies. These findings (a) confirm a unifying pathological role for prelamin A common to genetic and acquired cardiomyopathies; (b) have implications for the management of HIV patients with cardiac disease, suggesting protease inhibitors should be replaced with alternative therapies (i.e., nonnucleoside reverse transcriptase inhibitors); and (c) suggest that targeting inflammation may be a useful treatment strategy for certain forms of inherited cardiomyopathy.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.126315","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T12:00:30Z","timestamp":1571313630000},"source":"Crossref","is-referenced-by-count":36,"title":["Prelamin A mediates myocardial inflammation in dilated and HIV-associated cardiomyopathies"],"prefix":"10.1172","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2315-868X","authenticated-orcid":true,"given":"Daniel","family":"Brayson","sequence":"first","affiliation":[{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London BHF Centre for Research Excellence, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Frustaci","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Nefrologic, Anestesiologic and Geriatric Sciences, La Sapienza University of Rome, Italy."},{"name":"National Institute for Infectious Diseases IRCCS \u201cL. Spallanzani\u201d, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Verardo","sequence":"additional","affiliation":[{"name":"National Institute for Infectious Diseases IRCCS \u201cL. Spallanzani\u201d, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Chimenti","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Nefrologic, Anestesiologic and Geriatric Sciences, La Sapienza University of Rome, Italy."},{"name":"National Institute for Infectious Diseases IRCCS \u201cL. Spallanzani\u201d, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo Antonio","family":"Russo","sequence":"additional","affiliation":[{"name":"MEBIC Open University San Raffaele and IRCCS San Raffaele Pisana, Laboratory of Molecular and Cellular Pathology, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Hayward","sequence":"additional","affiliation":[{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London BHF Centre for Research Excellence, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadia","family":"Ahmad","sequence":"additional","affiliation":[{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London BHF Centre for Research Excellence, London, United 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