{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:21:33Z","timestamp":1789586493476,"version":"build-2803163510"},"reference-count":83,"publisher":"American Society for Clinical Investigation","issue":"10","license":[{"start":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T00:00:00Z","timestamp":1557964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Leibniz Center Infection","award":["LCI"],"award-info":[{"award-number":["LCI"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,16]]},"abstract":"<jats:p>\n                    Epidemiological findings indicate that coinfection with influenza viruses is associated with an increased risk of death in patients suffering from tuberculosis, but the underlying pathomechanisms are not well understood. In this study, we demonstrate that influenza A virus (IAV) coinfection rapidly impairs control of\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    (\n                    <jats:italic>Mtb<\/jats:italic>\n                    ) in C57BL\/6 mice. IAV coinfection was associated with significantly increased bacterial loads, reduced survival, and a substantial modulation of innate and adaptive immune defenses including an impaired onset and development of\n                    <jats:italic>Mtb<\/jats:italic>\n                    -specific CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell responses and the accumulation of macrophages with increased arginase-1 production in the lungs. Our findings strongly indicate that IAV coinfection compromises the host\u2019s ability to control\n                    <jats:italic>Mtb<\/jats:italic>\n                    infection via the production of IL-10, which was rapidly induced upon viral infection. The blockade of IL-10 receptor signaling reduced the bacterial load in coinfected mice to a level comparable to that in\n                    <jats:italic>Mtb<\/jats:italic>\n                    -only-infected animals. Taken together, our data suggest that IL-10 signaling constitutes a major pathway that enhances susceptibility to\n                    <jats:italic>Mtb<\/jats:italic>\n                    during concurrent IAV infection.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.126533","type":"journal-article","created":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T17:49:46Z","timestamp":1555609786000},"source":"Crossref","is-referenced-by-count":28,"title":["Blocking IL-10 receptor signaling ameliorates Mycobacterium tuberculosis infection during influenza-induced exacerbation"],"prefix":"10.1172","volume":"4","author":[{"given":"Sarah","family":"Ring","sequence":"first","affiliation":[{"name":"Junior Research Group Coinfection, Priority Research Area Infections, Research Center Borstel, Leibniz Lung Center, Borstel, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Eggers","sequence":"additional","affiliation":[{"name":"Junior Research Group Coinfection, Priority Research Area Infections, Research Center Borstel, Leibniz Lung Center, Borstel, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0648-8911","authenticated-orcid":true,"given":"Jochen","family":"Behrends","sequence":"additional","affiliation":[{"name":"Core Facility Fluorescence Cytometry, Research Center Borstel, Leibniz Lung Center, Borstel, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Wutkowski","sequence":"additional","affiliation":[{"name":"Bioanalytical Chemistry, Priority Research Area Infections, Research Center Borstel, Leibniz Lung Center, Borstel, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Schwudke","sequence":"additional","affiliation":[{"name":"Bioanalytical Chemistry, Priority Research Area Infections, Research Center Borstel, Leibniz Lung Center, Borstel, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Kr\u00f6ger","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hospital Hygiene, Otto-von-Guericke-University Magdeburg, and Innate Immunity and Infection, Helmholtz Centre for Infection Research, Braunschweig, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9351-4032","authenticated-orcid":true,"given":"Alexandra Maximiliane","family":"Hierweger","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine, Laboratory for Experimental Feto-Maternal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany."},{"name":"Institute for Immunology, Center for Diagnostics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"H\u00f6lscher","sequence":"additional","affiliation":[{"name":"Infection Immunology, Priority Research Area Infections, Research Center Borstel, Leibniz Lung Center, Borstel, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclsah","family":"Gabriel","sequence":"additional","affiliation":[{"name":"Research Department Viral Zoonoses - One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany."},{"name":"Institute of Virology, University of Veterinary Medicine, Hannover, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca E.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Junior Research Group Coinfection, Priority Research Area Infections, Research Center Borstel, Leibniz Lung Center, Borstel, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2019,5,16]]},"reference":[{"key":"B1","unstructured":"WHO. 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