{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:44:59Z","timestamp":1789991099794,"version":"4.0.1"},"reference-count":70,"publisher":"American Society for Clinical Investigation","issue":"6","funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["1F32DK115031-01"],"award-info":[{"award-number":["1F32DK115031-01"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["T32DK007012"],"award-info":[{"award-number":["T32DK007012"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006510","name":"Duke University","doi-asserted-by":"crossref","award":["Duke-NUS Collaborative Research Initiative Trainee Exchange Program"],"award-info":[{"award-number":["Duke-NUS Collaborative Research Initiative Trainee Exchange Program"]}],"id":[{"id":"10.13039\/100006510","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,21]]},"abstract":"<jats:p>\n                    Bariatric surgeries including vertical sleeve gastrectomy (VSG) ameliorate obesity and diabetes. Weight loss and accompanying increases to insulin sensitivity contribute to improved glycemia after surgery; however, studies in humans also suggest weight-independent actions of bariatric procedures to lower blood glucose, possibly by improving insulin secretion. To evaluate this hypothesis, we compared VSG-operated mice with pair-fed, sham-surgical controls (PF-Sham) 2 weeks after surgery. This paradigm yielded similar postoperative body weight and insulin sensitivity between VSG and calorically restricted PF-Sham animals. However, VSG improved glucose tolerance and markedly enhanced insulin secretion during oral nutrient and i.p. glucose challenges compared with controls. Islets from VSG mice displayed a unique transcriptional signature enriched for genes involved in Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling and insulin secretion pathways. This finding suggests that bariatric surgery leads to intrinsic changes within the islet that alter function. Indeed, islets isolated from VSG mice had increased glucose-stimulated insulin secretion and a left-shifted glucose sensitivity curve compared with islets from PF-Sham mice. Isolated islets from VSG animals showed corresponding increases in the pulse duration of glucose-stimulated Ca\n                    <jats:sup>2+<\/jats:sup>\n                    oscillations. Together, these findings demonstrate a weight-independent improvement in glycemic control following VSG, which is, in part, driven by improved insulin secretion and associated with substantial changes in islet gene expression. These results support a model in which \u03b2 cells play a key role in the adaptation to bariatric surgery and the improved glucose tolerance that is typical of these procedures.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.126688","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T12:02:02Z","timestamp":1550577722000},"source":"Crossref","is-referenced-by-count":20,"title":["Sleeve gastrectomy rapidly enhances islet function independently of body weight"],"prefix":"10.1172","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2299-6163","authenticated-orcid":true,"given":"Jonathan D.","family":"Douros","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Niu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Duke 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