{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:09:02Z","timestamp":1779196142504,"version":"3.51.4"},"reference-count":45,"publisher":"American Society for Clinical Investigation","issue":"15","funder":[{"name":"NIH","award":["HL091983,HL126186,HL134608"],"award-info":[{"award-number":["HL091983,HL126186,HL134608"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,8]]},"abstract":"<jats:p>\n                    Podoplanin (PDPN), a small mucin-type transmembrane glycoprotein, has been recently shown to be expressed by lymphangiogenic, fibrogenic, and mesenchymal progenitor cells in the acutely and chronically infarcted myocardium. PDPN binds to a C-type lectin\u2013like receptor 2 highly expressed by CD11b\n                    <jats:sup>hi<\/jats:sup>\n                    cells following inflammatory stimuli. Why PDPN expression appears only after organ injury is currently unknown. Here, we characterize the role of PDPN in different stages of myocardial repair after infarction and propose a PDPN-mediated mechanism in the resolution of post\u2013myocardial infarction (MI) inflammatory response and cardiac repair. Neutralization of PDPN led to significant improvements in the left ventricular (LV) functions and scar composition in animals treated with PDPN-neutralizing antibody. The inhibition of the interaction between PDPN and C-type lectin\u2013like receptor 2 expressing immune cells in the heart enhances the cardiac performance, regeneration, and angiogenesis after MI. Our data indicate that modulating the interaction between PDPN-positive cells with the immune cells after MI positively affects immune cell recruitment and may represent a novel therapeutic target to augment post-MI cardiac repair, regeneration, and function.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.126967","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T12:00:52Z","timestamp":1562673652000},"source":"Crossref","is-referenced-by-count":22,"title":["Podoplanin neutralization improves cardiac remodeling and function after myocardial infarction"],"prefix":"10.1172","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5414-6257","authenticated-orcid":true,"given":"Maria","family":"Cimini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkata Naga Srikanth","family":"Garikipati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4346-111X","authenticated-orcid":true,"given":"Claudio","family":"de Lucia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7667-2458","authenticated-orcid":true,"given":"Zhongjian","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunlin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"May M.","family":"Truongcao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7160-1626","authenticated-orcid":true,"given":"Anna Maria","family":"Lucchese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajika","family":"Roy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Benedict","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Goukassian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8522-530X","authenticated-orcid":true,"given":"Walter J.","family":"Koch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj","family":"Kishore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"232","published-online":{"date-parts":[[2019,8,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000003"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2015.07.002"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173927"},{"key":"B4","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2012.00283","article-title":"Podoplanin: emerging functions in development, the immune system, and cancer","volume":"3","author":"Astarita","year":"2012","journal-title":"Front Immunol"},{"issue":"3","key":"B5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20030707","article-title":"Podoplanin in inflammation and cancer","volume":"20","author":"Quintanilla","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-015-0424-9"},{"issue":"2","key":"B7","first-page":"370","article-title":"Podoplanin - 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