{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:38:29Z","timestamp":1790271509051,"version":"4.1.0"},"reference-count":23,"publisher":"American Society for Clinical Investigation","issue":"19","funder":[{"DOI":"10.13039\/501100001677","name":"INSERM","doi-asserted-by":"crossref","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"crossref","award":["ANR-18-CE14-0031-01"],"award-info":[{"award-number":["ANR-18-CE14-0031-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur le Cancer","doi-asserted-by":"crossref","award":["PJA20161204896"],"award-info":[{"award-number":["PJA20161204896"]}],"id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"crossref","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010466","name":"Chancellerie des Universit\u00e9s de Paris","doi-asserted-by":"crossref","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100010466","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,3]]},"abstract":"<jats:p>\n                    Oxidative stress is a major contributor to chronic lung diseases. Antioxidants such as\n                    <jats:italic>N<\/jats:italic>\n                    -acetylcysteine (NAC) are broadly viewed as protective molecules that prevent the mutagenic effects of reactive oxygen species. Antioxidants may, however, increase the risk of some forms of cancer and accelerate lung cancer progression in murine models. Here, we investigated chronic NAC treatment in aging mice displaying lung oxidative stress and cell senescence due to inactivation of the transcription factor\n                    <jats:italic>JunD<\/jats:italic>\n                    , which is downregulated in diseased human lungs. NAC treatment decreased lung oxidative damage and cell senescence and protected from lung emphysema but concomitantly induced the development of lung adenocarcinoma in 50% of\n                    <jats:italic>JunD<\/jats:italic>\n                    -deficient mice and 10% of aged control mice. This finding constitutes the first evidence to our knowledge of a carcinogenic effect of antioxidant therapy in the lungs of aged mice with chronic lung oxidative stress and warrants the utmost caution when considering the therapeutic use of antioxidants.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.127647","type":"journal-article","created":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T11:00:55Z","timestamp":1570014055000},"source":"Crossref","is-referenced-by-count":55,"title":["The antioxidant N-acetylcysteine protects from lung emphysema but induces lung adenocarcinoma in mice"],"prefix":"10.1172","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6107-9547","authenticated-orcid":true,"given":"Marielle","family":"Breau","sequence":"first","affiliation":[{"name":"INSERM U955, D\u00e9partement de Physiologie-Explorations Fonctionnelles, and DHU A-TVB H\u00f4pital Henri Mondor, AP-HP, Cr\u00e9teil, 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