{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:58:31Z","timestamp":1790787511404,"version":"4.1.0"},"reference-count":74,"publisher":"American Society for Clinical Investigation","issue":"11","funder":[{"name":"Women and Children\u2019s Health Reserch Institute","award":["Not porvided"],"award-info":[{"award-number":["Not porvided"]}]},{"DOI":"10.13039\/501100000038","name":"National Sciences and Engineering REsearch Council of Canada","doi-asserted-by":"crossref","award":["05842"],"award-info":[{"award-number":["05842"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]},{"name":"DFG","award":["894"],"award-info":[{"award-number":["894"]}]},{"name":"Fabrikant Vilhelm Pedersen og Hustrus Mindelegat","award":["not provided"],"award-info":[{"award-number":["not provided"]}]},{"DOI":"10.13039\/501100009708","name":"the Novo Nordisk Foundation","doi-asserted-by":"crossref","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Independent Research Fund Denmark","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,6]]},"abstract":"<jats:p>\n                    Plasma calcium (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ) is maintained by amending the release of parathyroid hormone and through direct effects of the Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -sensing receptor (CaSR) in the renal tubule. Combined, these mechanisms alter intestinal Ca\n                    <jats:sup>2+<\/jats:sup>\n                    absorption by modulating 1,25-dihydroxyvitamin D\n                    <jats:sub>3<\/jats:sub>\n                    production, bone resorption, and renal Ca\n                    <jats:sup>2+<\/jats:sup>\n                    excretion. The CaSR is a therapeutic target in the treatment of secondary hyperparathyroidism and hypocalcemia, a common complication of calcimimetic therapy. The CaSR is also expressed in intestinal epithelium; however, a direct role in regulating local intestinal Ca\n                    <jats:sup>2+<\/jats:sup>\n                    absorption is unknown. Chronic CaSR activation decreased expression of genes involved in Ca\n                    <jats:sup>2+<\/jats:sup>\n                    absorption. In Ussing chambers, increasing extracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    or basolateral application of the calcimimetic cinacalcet decreased net Ca\n                    <jats:sup>2+<\/jats:sup>\n                    absorption across intestinal preparations acutely. Conversely, Ca\n                    <jats:sup>2+<\/jats:sup>\n                    absorption increased with decreasing extracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    concentration. These responses were absent in mice expressing a nonfunctional TRPV6, TRPV6\n                    <jats:sup>D541A<\/jats:sup>\n                    . Cinacalcet also attenuated Ca\n                    <jats:sup>2+<\/jats:sup>\n                    fluxes through TRPV6 in\n                    <jats:italic>Xenopus<\/jats:italic>\n                    oocytes when coexpressed with the CaSR. Moreover, the phospholipase C inhibitor U73122 prevented cinacalcet-mediated inhibition of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    flux. These results reveal a regulatory pathway whereby activation of the CaSR in the basolateral membrane of the intestine directly attenuates local Ca\n                    <jats:sup>2+<\/jats:sup>\n                    absorption via TRPV6 to prevent hypercalcemia and help explain how calcimimetics induce hypocalcemia.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.128013","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T12:03:37Z","timestamp":1556021017000},"source":"Crossref","is-referenced-by-count":36,"title":["Activation of the calcium-sensing receptor attenuates TRPV6-dependent intestinal calcium absorption"],"prefix":"10.1172","volume":"4","author":[{"given":"Justin J.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Alberta, Edmonton, Alberta, Canada."},{"name":"The Women\u2019s and Children\u2019s Health Research Institute, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"O\u2019Neill","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan R.","family":"Beggs","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Alberta, Edmonton, Alberta, Canada."},{"name":"The Women\u2019s and Children\u2019s Health Research Institute, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Weissgerber","sequence":"additional","affiliation":[{"name":"Experimentelle und Klinische Pharmakologie und Toxikologie, Saarland University, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veit","family":"Flockerzi","sequence":"additional","affiliation":[{"name":"Experimentelle und Klinische Pharmakologie und Toxikologie, Saarland University, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Zhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9170-2168","authenticated-orcid":true,"given":"Henrik","family":"Dimke","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark."},{"name":"Department of Nephrology, Odense University Hospital, Odense, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7396-7894","authenticated-orcid":true,"given":"R. 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