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Here, we outline how emerging technologies increasingly enable an integrated view of how immune cells and PNS parenchymal cells communicate in CIDP. We also relate the known heterogeneity of clinical presentation with specific underlying mechanisms. For example, a severe subtype of CIDP with tremor is associated with pathogenic IgG4 autoantibodies against nodal and paranodal proteins. An improved understanding of pathogenic mechanisms in CIDP will form the basis for more effective mechanism-based therapies.<\/jats:p>","DOI":"10.1172\/jci.insight.132411","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T16:11:52Z","timestamp":1581523912000},"source":"Crossref","is-referenced-by-count":38,"title":["Deciphering immune mechanisms in chronic inflammatory demyelinating polyneuropathies"],"prefix":"10.1172","volume":"5","author":[{"given":"Jolien","family":"Wolbert","sequence":"first","affiliation":[{"name":"Department of Neurology with Institute of Translational Neurology, University Hospital M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy I.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Microbiology Immunology and Medical Genetics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4341-4719","authenticated-orcid":true,"given":"Gerd Meyer zu","family":"Horste","sequence":"additional","affiliation":[{"name":"Department of Neurology with Institute of Translational Neurology, University Hospital M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen A.","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Microbiology Immunology and Medical Genetics and"},{"name":"Department of Pediatrics, UCLA, Los Angeles, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2020,2,13]]},"reference":[{"issue":"9","key":"B1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nrneurol.2011.121","article-title":"Advances in the diagnosis, pathogenesis and treatment of CIDP","volume":"7","author":"Dalakas","year":"2011","journal-title":"Nat Rev Neurol"},{"issue":"11","key":"B2","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0025-6196(25)09732-0","article-title":"Chronic inflammatory polyradiculoneuropathy","volume":"50","author":"Dyck","year":"1975","journal-title":"Mayo Clin Proc"},{"issue":"Pt 6","key":"B3","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1093\/brain\/110.6.1617","article-title":"Chronic inflammatory demyelinating polyradiculoneuropathy. 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