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To address this, we designed an aberrant uterine hypercontractility paradigm with oxytocin to better assess the consequences of acute, but transient, placental ischemia-hypoxemia in term pregnant rats. Using MRI, we confirmed that oxytocin-induced aberrant uterine hypercontractility substantially compromised uteroplacental perfusion. This was supported by the observation of oxidative stress and increased lactate concentration in the fetal brain. Genes related to oxidative stress pathways were significantly upregulated in male, but not female, offspring 1 hour after oxytocin-induced placental ischemia-hypoxemia. Persistent upregulation of select mitochondrial electron transport chain complex proteins in the anterior cingulate cortex of adolescent male offspring suggested that this sex-specific effect was enduring. Functionally, offspring exposed to oxytocin-induced uterine hypercontractility showed male-specific abnormalities in social behavior with associated region-specific changes in gene expression and functional cortical connectivity. Our findings, therefore, indicate that even transient but severe placental ischemia-hypoxemia could be detrimental to the developing brain and point to a possible mitochondrial link between intrauterine asphyxia and neurodevelopmental disorders.<\/jats:p>","DOI":"10.1172\/jci.insight.133172","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T11:01:32Z","timestamp":1589972492000},"source":"Crossref","is-referenced-by-count":22,"title":["In utero exposure to transient ischemia-hypoxemia promotes long-term neurodevelopmental abnormalities in male rat offspring"],"prefix":"10.1172","volume":"5","author":[{"given":"Arvind","family":"Palanisamy","sequence":"first","affiliation":[{"name":"Department of Anesthesiology,"},{"name":"Department of Obstetrics and Gynecology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tusar","family":"Giri","sequence":"additional","affiliation":[{"name":"Department of 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