{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:03:21Z","timestamp":1791597801583,"version":"4.3.4"},"reference-count":44,"publisher":"American Society for Clinical Investigation","issue":"9","funder":[{"DOI":"10.13039\/100000072","name":"NIDCR","doi-asserted-by":"crossref","award":["Intramural"],"award-info":[{"award-number":["Intramural"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH\/NIDCR","award":["Intram"],"award-info":[{"award-number":["Intram"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,7]]},"abstract":"<jats:p>\n                    Sj\u00f6gren\u2019s syndrome (SS) is a systemic autoimmune disease that mainly affects exocrine salivary and lacrimal glands. Local inflammation in the glands is thought to trigger glandular dysfunction and symptoms of dryness. However, the mechanisms underlying these processes are incompletely understood. Our work suggests T cell exosome\u2013derived miR-142-3p as a pathogenic driver of immunopathology in SS. We first document miR-142-3p expression in the salivary glands of patients with SS, both in epithelial gland cells and within T cells of the inflammatory infiltrate, but not in healthy volunteers. Next, we show that activated T cells secreted exosomes containing miR-142-3p, which transferred into glandular cells. Finally, we uncover a functional role of miR-142-3p\u2013containing exosomes in glandular cell dysfunction. We find that miR-142-3p targets key elements of intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling and cAMP production \u2014 sarco(endo)plasmic reticulum Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ATPase 2b (SERCA2B), ryanodine receptor 2 (RyR2), and adenylate cyclase 9 (AC9) \u2014 leading to restricted cAMP production, altered calcium signaling, and decreased protein production from salivary gland cells. Our work provides evidence for a functional role of the miR-142-3p in SS pathogenesis and promotes the concept that T cell activation may directly impair epithelial cell function through secretion of miRNA-containing exosomes.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.133497","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T11:01:37Z","timestamp":1588762897000},"source":"Crossref","is-referenced-by-count":76,"title":["T cell exosome\u2013derived miR-142-3p impairs glandular cell function in Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1172","volume":"5","author":[{"given":"Juan","family":"Cortes-Troncoso","sequence":"first","affiliation":[{"name":"Sj\u00f6gren\u2019s Syndrome and Salivary Gland Dysfunction Unit,"},{"name":"Oral Immunity and Inflammation Section, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyh-Ing","family":"Jang","sequence":"additional","affiliation":[{"name":"Sj\u00f6gren\u2019s Syndrome 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