{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:47:12Z","timestamp":1788346032942,"version":"build-2803163510"},"reference-count":74,"publisher":"American Society for Clinical Investigation","issue":"19","license":[{"start":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T00:00:00Z","timestamp":1601596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2017YFB0403803"],"award-info":[{"award-number":["2017YFB0403803"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31930042,31771164"],"award-info":[{"award-number":["31930042,31771164"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shanghai Municipal Science and Technology Major Project grant and funds from ZJLab","award":["No. 2018SHZDZX01"],"award-info":[{"award-number":["No. 2018SHZDZX01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,2]]},"abstract":"<jats:p>\n                    Depression and anxiety are frequently observed in patients suffering from neuropathic pain. The underlying mechanisms remained unclear. The ventrolateral orbital cortex (VLO) has attracted considerable interest in its role in antidepressive effect in rodents. In the present study, we further investigated the role of the VLO in the anxiodepressive consequences of neuropathic pain in a chronic constriction injury of infraorbital nerve\u2013induced trigeminal neuralgia (TN) mouse model. Elevated plus maze, open field, forced swimming, tail suspension, and sucrose preference tests were used to evaluate anxiodepressive-like behaviors. The results show that chemogenetic activation of bilateral VLO neurons, especially CaMK2A\n                    <jats:sup>+<\/jats:sup>\n                    pyramidal neurons, blocked the TN-induced anxiodepressive-like behaviors. Chemogenetic and optogenetic activation of VGLUT2\n                    <jats:sup>+<\/jats:sup>\n                    or inhibition of VGAT\n                    <jats:sup>+<\/jats:sup>\n                    VLO neurons was sufficient to produce an antianxiodepressive effect in TN mice. Pharmacological activation of D1-like receptors (D1Rs) but not D2Rs in the VLO significantly alleviated TN-induced depressive-like behaviors. Electrophysiological recordings revealed a decreased excitability of VLO excitatory neurons following neuropathic pain. Furthermore, activation of submedius thalamic nucleus\u2013VLO (Sm-VLO) projection mimicked the antianxiodepressive effect of VLO excitation. Conversely, activation of VLO-periaqueductal gray matter (PAG) projection had no effect on TN-induced anxiodepressive behaviors. This study provides a potentially novel mechanism\u2013based therapeutic strategy for the anxiodepressive consequences of neuropathic pain.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.133625","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T11:01:40Z","timestamp":1601550100000},"source":"Crossref","is-referenced-by-count":41,"title":["Activation of ventrolateral orbital cortex improves mouse neuropathic pain\u2013induced anxiodepression"],"prefix":"10.1172","volume":"5","author":[{"given":"Hai-Yan","family":"Sheng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Department of Translational Neuroscience, Jing\u2019an District Centre Hospital of Shanghai, Institutes of Brain Science, Fudan University, Shanghai, China."},{"name":"Department of Pathophysiology, School of Basic Medical Sciences, Xinxiang Medical University, Henan, 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