{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:01:44Z","timestamp":1790532104532,"version":"4.1.0"},"reference-count":50,"publisher":"American Society for Clinical Investigation","issue":"5","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 AI 118833"],"award-info":[{"award-number":["R01 AI 118833"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,12]]},"abstract":"<jats:p>\n                    Relatively little is known about interactions between the airway microbiome and airway host transcriptome in asthma. Since asthma affects and is affected by the entire airway, studying the upper (e.g., nasal) and lower (e.g., bronchial) airways together represents a powerful approach to understanding asthma. Here, we performed a systematic, integrative study of the nasal and bronchial microbiomes and nasal and bronchial host transcriptomes of children with severe persistent asthma and healthy controls. We found that (a) the microbiomes and host transcriptomes of asthmatic children are each distinct by site (nasal versus bronchial); (b) among asthmatic children,\n                    <jats:italic>Moraxella<\/jats:italic>\n                    and\n                    <jats:italic>Alloiococcus<\/jats:italic>\n                    are hub genera in the nasal microbiome, while there are no hubs among bronchial genera; (c) bronchial\n                    <jats:italic>Actinomyces<\/jats:italic>\n                    is negatively associated with bronchial genes for inflammation, suggesting\n                    <jats:italic>Actinomyces<\/jats:italic>\n                    may be protective; (d) compared with healthy children, asthmatic children express more nasal genes for ciliary function and harbor more nasal\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    ; and (e) nasal genera such as\n                    <jats:italic>Corynebacterium<\/jats:italic>\n                    are negatively associated with significantly more nasal genes for inflammation in healthy versus asthmatic children, suggesting a potentially stronger protective role for such nasal genera in healthy versus asthmatic children. Our systematic, integrative study provides a window into host-microbiome associations in asthma.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.133707","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T11:01:43Z","timestamp":1583924503000},"source":"Crossref","is-referenced-by-count":66,"title":["Integrative study of the upper and lower airway microbiome and transcriptome in asthma"],"prefix":"10.1172","volume":"5","author":[{"given":"Yoojin","family":"Chun","sequence":"first","affiliation":[{"name":"Institute for Data Science and Genomic Technology, Department of Genetics and Genomic Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh","family":"Do","sequence":"additional","affiliation":[{"name":"Institute for Data Science and Genomic Technology, Department of Genetics and Genomic 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