{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:03:39Z","timestamp":1792047819596,"version":"4.4.0"},"reference-count":79,"publisher":"American Society for Clinical Investigation","issue":"5","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AI134962"],"award-info":[{"award-number":["AI134962"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,12]]},"abstract":"<jats:p>Herpes simplex virus-2 (HSV-2) and HSV-1 both can cause genital herpes, a chronic infection that establishes a latent reservoir in the nervous system. Clinically, the recurrence frequency of HSV-1 genital herpes is considerably less than HSV-2 genital herpes, which correlates with reduced neuronal infection. The factors dictating the disparate outcomes of HSV-1 and HSV-2 genital herpes are unclear. In this study, we show that vaginal infection of mice with HSV-1 leads to the rapid appearance of mature DCs in the draining lymph node, which is dependent on an early burst of NK cell\u2013mediated IFN-\u03b3 production in the vagina that occurs after HSV-1 infection but not HSV-2 infection. Rapid DC maturation after HSV-1 infection, but not HSV-2 infection, correlates with the accelerated generation of a neuroprotective T cell response and early accumulation of IFN-\u03b3\u2013producing T cells at the site of infection. Depletion of T cells or loss of IFN-\u03b3 receptor (IFN-\u03b3R) expression in sensory neurons both lead to a marked loss of neuroprotection only during HSV-1, recapitulating a prominent feature of HSV-2 infection. Our experiments reveal key differences in host control of neuronal HSV-1 and HSV-2 infection after genital exposure of mice, and they define parameters of a successful immune response against genital herpes.<\/jats:p>","DOI":"10.1172\/jci.insight.134258","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T11:01:43Z","timestamp":1583924503000},"source":"Crossref","is-referenced-by-count":18,"title":["T cell response kinetics determines neuroinfection outcomes during murine HSV infection"],"prefix":"10.1172","volume":"5","author":[{"given":"Aisha G.","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Scott","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria 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