{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:39:48Z","timestamp":1787787588484,"version":"build-2784847793"},"reference-count":36,"publisher":"American Society for Clinical Investigation","issue":"11","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["DK-64008,DK-83781"],"award-info":[{"award-number":["DK-64008,DK-83781"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,4]]},"abstract":"<jats:p>\n                    Extramedullary hematopoietic cells are present in the liver of normal neonates in the first few days of life and persist in infants with biliary atresia. Based on a previous report that liver genes are enriched by erythroid pathways, we examined the liver gene expression pattern at diagnosis and found the top 5 enriched pathways are related to erythrocyte pathobiology in children who survived with the native liver beyond 2 years of age. Using immunostaining, anti-CD71 antibodies identified CD71\n                    <jats:sup>+<\/jats:sup>\n                    erythroid cells among extramedullary hematopoietic cells in the livers at the time of diagnosis. In mechanistic experiments, the preemptive antibody depletion of hepatic CD71\n                    <jats:sup>+<\/jats:sup>\n                    erythroid cells in neonatal mice rendered them resistant to rhesus rotavirus\u2013induced (RRV-induced)  biliary atresia. The depletion of CD71\n                    <jats:sup>+<\/jats:sup>\n                    erythroid cells increased the number of effector lymphocytes and delayed the RRV infection of livers and extrahepatic bile ducts. In coculture experiments, CD71\n                    <jats:sup>+<\/jats:sup>\n                    erythroid cells suppressed the activation of hepatic mononuclear cells. These data uncover an immunoregulatory role for CD71\n                    <jats:sup>+<\/jats:sup>\n                    erythroid cells in the neonatal liver.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.135751","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T12:02:14Z","timestamp":1589457734000},"source":"Crossref","is-referenced-by-count":12,"title":["Regulation of bile duct epithelial injury by hepatic CD71+ erythroid cells"],"prefix":"10.1172","volume":"5","author":[{"given":"Li","family":"Yang","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children\u2019s Hospital Medical Center (CCHMC) and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA."},{"name":"Division of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2095-0623","authenticated-orcid":true,"given":"Pranavkumar","family":"Shivakumar","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children\u2019s Hospital Medical Center (CCHMC) and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Kinder","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Perinatal Institute and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8948-1952","authenticated-orcid":true,"given":"Sing Sing","family":"Way","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Perinatal Institute 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