{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:30:44Z","timestamp":1788813044917,"version":"build-2803163510"},"reference-count":36,"publisher":"American Society for Clinical Investigation","issue":"15","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2016YFC1302200"],"award-info":[{"award-number":["2016YFC1302200"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81870394"],"award-info":[{"award-number":["81870394"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81872016"],"award-info":[{"award-number":["81872016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,6]]},"abstract":"<jats:p>\n                    Arrestin domain containing 3 (ARRDC3) represents a newly discovered \u03b1-arrestin involved in obesity, inflammation, and cancer. Here, we demonstrate a proinflammation role of ARRDC3 in\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    \u2013associated gastritis. Increased ARRDC3 was detected in gastric mucosa of patients and mice infected with\n                    <jats:italic>H<\/jats:italic>\n                    .\n                    <jats:italic>pylori<\/jats:italic>\n                    . ARRDC3 in gastric epithelial cells (GECs) was induced by\n                    <jats:italic>H<\/jats:italic>\n                    .\n                    <jats:italic>pylori<\/jats:italic>\n                    , regulated by ERK and PI3K-AKT pathways in a\n                    <jats:italic>cagA<\/jats:italic>\n                    -dependent manner. Human gastric ARRDC3 correlated with the severity of gastritis, and mouse ARRDC3 from non-BM\u2013derived cells promoted gastric inflammation. This inflammation was characterized by the CXCR2-dependent influx of CD45\n                    <jats:sup>+<\/jats:sup>\n                    CD11b\n                    <jats:sup>+<\/jats:sup>\n                    Ly6C\n                    <jats:sup>\u2013<\/jats:sup>\n                    Ly6G\n                    <jats:sup>+<\/jats:sup>\n                    neutrophils, whose migration was induced via the ARRDC3-dependent production of CXCL2 by GECs. Importantly, gastric inflammation was attenuated in\n                    <jats:italic>\n                      Arrdc3\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice but increased in protease-activated receptor 1\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    (\n                    <jats:italic>Par1<\/jats:italic>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    ) mice. Mechanistically, ARRDC3 in GECs directly interacted with PAR1 and negatively regulated PAR1 via ARRDC3-mediated lysosomal degradation, which abrogated the suppression of CXCL2 production and following neutrophil chemotaxis by PAR1, thereby contributing to the development of\n                    <jats:italic>H<\/jats:italic>\n                    .\n                    <jats:italic>pylori<\/jats:italic>\n                    \u2013associated gastritis. This study identifies a regulatory network involving\n                    <jats:italic>H<\/jats:italic>\n                    .\n                    <jats:italic>pylori<\/jats:italic>\n                    , GECs, ARRDC3, PAR1, and neutrophils, which collectively exert a proinflammatory effect within the gastric microenvironment. Efforts to inhibit this ARRDC3-dependent pathway may provide valuable strategies in treating of\n                    <jats:italic>H<\/jats:italic>\n                    .\n                    <jats:italic>pylori<\/jats:italic>\n                    \u2013associated gastritis.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.135849","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T12:13:52Z","timestamp":1594124032000},"source":"Crossref","is-referenced-by-count":19,"title":["Arrestin domain containing 3 promotes Helicobacter pylori\u2013associated gastritis by regulating protease-activated receptor 1"],"prefix":"10.1172","volume":"5","author":[{"given":"Yu-gang","family":"Liu","sequence":"first","affiliation":[{"name":"National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Third Military Medical University, Chongqing, China."},{"name":"Department of Clinical Laboratory, the General Hospital of Western Theater Command, Chengdu, Sichuan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-sheng","family":"Teng","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Third Military Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-guo","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Center of Minimal Invasive Gastrointestinal Surgery, Southwest Hospital, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Cheng","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Third Military Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-jie","family":"Hao","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Third Military Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-pin","family":"Lv","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Third Military Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-yuan","family":"Mao","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Third Military Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-ming","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, XinQiao Hospital, Third Military Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5221-9771","authenticated-orcid":true,"given":"Weisan","family":"Chen","sequence":"additional","affiliation":[{"name":"La Trobe Institute of Molecular Science, La Trobe University, Bundoora, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-liang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Center of Minimal Invasive Gastrointestinal Surgery, Southwest Hospital, 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