{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T21:35:16Z","timestamp":1794260116758,"version":"4.9.0"},"reference-count":66,"publisher":"American Society for Clinical Investigation","issue":"10","funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["R21AI130918,U19AI111211,R01AI087465,T32AI074492,K23AI144040,K24AI114444"],"award-info":[{"award-number":["R21AI130918,U19AI111211,R01AI087465,T32AI074492,K23AI144040,K24AI114444"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"crossref","award":["UL1TR002378"],"award-info":[{"award-number":["UL1TR002378"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012182","name":"Emory Medical Care Foundation","doi-asserted-by":"crossref","award":["2016\/06-0002"],"award-info":[{"award-number":["2016\/06-0002"]}],"id":[{"id":"10.13039\/100012182","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,21]]},"abstract":"<jats:p>\n                    There is limited understanding of the role of host metabolism in the pathophysiology of human tuberculosis (TB). Using high-resolution metabolomics with an unbiased approach to metabolic pathway analysis, we discovered that the tryptophan pathway is highly regulated throughout the spectrum of TB infection and disease. This regulation is characterized by increased catabolism of tryptophan to kynurenine, which was evident not only in active TB disease but also in latent TB infection (LTBI). Further, we found that tryptophan catabolism is reversed with effective treatment of both active TB disease and LTBI in a manner commensurate with bacterial clearance. Persons with active TB and LTBI also exhibited increased expression of\n                    <jats:italic>indoleamine 2,3-dioxygenase-1<\/jats:italic>\n                    (\n                    <jats:italic>IDO-1<\/jats:italic>\n                    ), suggesting IDO-1 mediates observed increases in tryptophan catabolism. Together, these data indicate IDO-1\u2013mediated tryptophan catabolism is highly preserved in the human response to\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    and could be a target for biomarker development as well as host-directed therapies.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.137131","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T12:43:59Z","timestamp":1588682639000},"source":"Crossref","is-referenced-by-count":98,"title":["Tryptophan catabolism reflects disease activity in human tuberculosis"],"prefix":"10.1172","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6574-0873","authenticated-orcid":true,"given":"Jeffrey M.","family":"Collins","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amnah","family":"Siddiqa","sequence":"additional","affiliation":[{"name":"Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2090-0677","authenticated-orcid":true,"given":"Dean P.","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9736-5828","authenticated-orcid":true,"given":"Ken","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7188-4996","authenticated-orcid":true,"given":"Russell R.","family":"Kempker","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azhar","family":"Nizam","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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