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In an effort to bridge this gap, we evaluated cryopreserved PBMCs from 4 patients who survived Ebola virus disease (EVD) using an established mass cytometry antibody panel to characterize various cell populations during both the acute and convalescent phases. Acute loss of nonclassical monocytes and myeloid DCs, especially CD1c\n                    <jats:sup>+<\/jats:sup>\n                    DCs, was noted. Classical monocyte proliferation and CD38 upregulation on plasmacytoid DCs coincided with declining viral load. Unsupervised analysis of cell abundance demonstrated acute declines in monocytic, NK, and T cell populations, but some populations, many of myeloid origin, increased in abundance during the acute phase, suggesting emergency hematopoiesis. Despite cell losses during the acute phase, upregulation of Ki-67 correlated with recovery of cell populations over time. These data provide insights into the human immune response during EVD.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.137260","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T11:01:32Z","timestamp":1589972492000},"source":"Crossref","is-referenced-by-count":34,"title":["Immunologic timeline of Ebola virus disease and recovery in humans"],"prefix":"10.1172","volume":"5","author":[{"given":"Anita K.","family":"McElroy","sequence":"first","affiliation":[{"name":"Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA."},{"name":"Division of Pediatric Infectious Diseases and Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rama S.","family":"Akondy","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Emory University School of Medicine, Atlanta, 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