{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:33:28Z","timestamp":1792787608098,"version":"4.5.0"},"reference-count":37,"publisher":"American Society for Clinical Investigation","issue":"18","license":[{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"S National Institutes of Health","award":["P01 - AI123086"],"award-info":[{"award-number":["P01 - AI123086"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,17]]},"abstract":"<jats:p>\n                    In swine and nonhuman primates, kidney allografts can induce tolerance of heart allografts, leading to their long-term, immunosuppression-free survival. We refer to this phenomenon as kidney-induced cardiac allograft tolerance (KICAT). In this study, we have developed a murine model for KICAT to determine the underlining cellular\/molecular mechanisms. Here, we show that spontaneously accepted DBA\/2J kidneys in C57BL\/6 recipients induce systemic tolerance that results in the long-term acceptance of DBA\/2J heart allografts but not third-party cardiac allografts. The state of systemic tolerance of hearts was established 2 weeks after transplantation of the kidney, after which time, the kidney allograft is no longer required. Depletion of Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    T cells from these mice precipitated rejection of the heart allografts, indicating that KICAT is dependent on Treg function. Acceptance of kidney allografts and cotransplanted heart allografts did not require the thymus. In conclusion, these data show that kidney allografts induce systemic, donor-specific tolerance of cardiac allografts via Foxp3 cells, and that tolerance is independent of the thymus and continued presence of the kidney allograft. This experimental system should promote increased understanding of the tolerogenic mechanisms of the kidney.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.139331","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T11:01:14Z","timestamp":1600254074000},"source":"Crossref","is-referenced-by-count":22,"title":["Kidney-induced systemic tolerance of heart allografts in mice"],"prefix":"10.1172","volume":"5","author":[{"given":"Chao","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, China."},{"name":"Center for Transplantation Sciences, Department of Surgery, and"},{"name":"Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifu","family":"Ge","sequence":"additional","affiliation":[{"name":"Center for Transplantation Sciences, Department of Surgery, and"},{"name":"Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China."},{"name":"Department of Surgery, Boston Children\u2019s Hospital, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivy","family":"Rosales","sequence":"additional","affiliation":[{"name":"Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yuan","sequence":"additional","affiliation":[{"name":"Center for Transplantation Sciences, Department of Surgery, and"},{"name":"Organ Transplant Institute, 8th Medical Center, Chinese PLA General Hospital, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Szuter","sequence":"additional","affiliation":[{"name":"Center for Transplantation Sciences, Department of Surgery, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Acheampong","sequence":"additional","affiliation":[{"name":"Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Russell","sequence":"additional","affiliation":[{"name":"Center for Transplantation Sciences, Department of Surgery, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2724-1333","authenticated-orcid":true,"given":"Joren C.","family":"Madsen","sequence":"additional","affiliation":[{"name":"Center for Transplantation Sciences, Department of Surgery, and"},{"name":"Division of Cardiac Surgery, 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