{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:04:00Z","timestamp":1789387440952,"version":"build-2803163510"},"reference-count":30,"publisher":"American Society for Clinical Investigation","issue":"16","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":370,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,20]]},"abstract":"<jats:p>\n                    Skin lesions in dermatomyositis (DM) are common, are frequently refractory, and have prognostic significance. Histologically, DM lesions appear similar to cutaneous lupus erythematosus (CLE) lesions and frequently cannot be differentiated. We thus compared the transcriptional profile of DM biopsies with CLE lesions to identify unique features. Type I IFN signaling, including IFN-\u03ba upregulation, was a common pathway in both DM and CLE; however, CLE also exhibited other inflammatory pathways. Notably, DM lesions could be distinguished from CLE by a 5-gene biomarker panel that included\n                    <jats:italic>IL18<\/jats:italic>\n                    upregulation. Using single-cell RNA-sequencing, we further identified keratinocytes as the main source of increased IL-18 in DM skin. This study identifies a potentially novel molecular signature, with significant clinical implications for differentiating DM from CLE lesions, and highlights the potential role for IL-18 in the pathophysiology of DM skin disease.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.139558","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T12:01:00Z","timestamp":1594296060000},"source":"Crossref","is-referenced-by-count":45,"title":["IL18-containing 5-gene signature distinguishes histologically identical dermatomyositis and lupus erythematosus skin lesions"],"prefix":"10.1172","volume":"5","author":[{"given":"Lam C.","family":"Tsoi","sequence":"first","affiliation":[{"name":"Department of Dermatology and"},{"name":"Department of Computational Medicine & Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan, USA."},{"name":"Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrnaz","family":"Gharaee-Kermani","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3539-1075","authenticated-orcid":true,"given":"Celine C.","family":"Berthier","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tori","family":"Nault","sequence":"additional","affiliation":[{"name":"Division of General Medicine, Department of Internal Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace A.","family":"Hile","sequence":"additional","affiliation":[{"name":"Department of Dermatology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9225-6729","authenticated-orcid":true,"given":"Shannon N.","family":"Estadt","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine,"},{"name":"Program in Immunology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6174-9002","authenticated-orcid":true,"given":"Matthew T.","family":"Patrick","sequence":"additional","affiliation":[{"name":"Department of Dermatology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Wasikowski","sequence":"additional","affiliation":[{"name":"Department of Dermatology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7115-9113","authenticated-orcid":true,"given":"Allison C.","family":"Billi","sequence":"additional","affiliation":[{"name":"Department of Dermatology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2359-8426","authenticated-orcid":true,"given":"Lori","family":"Lowe","sequence":"additional","affiliation":[{"name":"Department of Dermatology and"},{"name":"Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamra J.","family":"Reed","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann E.","family":"Gudjonsson","sequence":"additional","affiliation":[{"name":"Department of Dermatology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4006-8945","authenticated-orcid":true,"given":"J. 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