{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:53:20Z","timestamp":1781225600648,"version":"3.54.1"},"reference-count":21,"publisher":"American Society for Clinical Investigation","issue":"2","license":[{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"crossref","award":["R01 AI120033"],"award-info":[{"award-number":["R01 AI120033"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"crossref","award":["R35 HL139930"],"award-info":[{"award-number":["R35 HL139930"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,25]]},"abstract":"<jats:p>\n                    <jats:italic>Pneumocystis<\/jats:italic>\n                    is an important opportunistic fungus that causes pneumonia in children and immunocompromised individuals. Recent genomic data show that divergence of major surface glycoproteins may confer speciation and host range selectivity. On the other hand, immune clearance between mice and humans is well correlated. Thus, we hypothesized that humanize mice may provide information about human immune responses involved in controlling\n                    <jats:italic>Pneumocystis<\/jats:italic>\n                    infection. CD34-engrafted huNOG-EXL mice controlled fungal burdens to a greater extent than nonengrafted mice. Moreover, engrafted mice generated fungal-specific IgM. Fungal control was associated with a transcriptional signature that was enriched for genes associated with nonopsonic recognition of trophs (\n                    <jats:italic>CD209<\/jats:italic>\n                    ) and asci (\n                    <jats:italic>CLEC7A<\/jats:italic>\n                    ). These same genes were downregulated in CD4-deficient mice as well as twins with bare lymphocyte syndrome with\n                    <jats:italic>Pneumocystis<\/jats:italic>\n                    pneumonia.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.139573","type":"journal-article","created":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T14:01:40Z","timestamp":1611496900000},"source":"Crossref","is-referenced-by-count":8,"title":["Toward a humanized mouse model of Pneumocystis pneumonia"],"prefix":"10.1172","volume":"6","author":[{"given":"Guixiang","family":"Dai","sequence":"first","affiliation":[{"name":"Center for Translational Research in Infection and Inflammation, Tulane School of Medicine, New Orleans, Louisiana, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alanna","family":"Wanek","sequence":"additional","affiliation":[{"name":"Center for Translational Research in Infection and Inflammation, Tulane School of Medicine, New Orleans, Louisiana, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Eddens","sequence":"additional","affiliation":[{"name":"UPMC Children\u2019s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Volden","sequence":"additional","affiliation":[{"name":"Taconic Biosciences, Germantown, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5151-6304","authenticated-orcid":true,"given":"Jay K.","family":"Kolls","sequence":"additional","affiliation":[{"name":"Center for Translational Research in Infection and Inflammation, Tulane School of Medicine, New Orleans, Louisiana, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2021,1,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008524"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.33.3.718-724.1995"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.4.2446-2448.2006"},{"issue":"4","key":"B4","doi-asserted-by":"crossref","first-page":"e00850","DOI":"10.1128\/IAI.00850-16","article-title":"Immunization with Pneumocystis cross-reactive antigen 1 (Pca1) protects mice against Pneumocystis pneumonia and generates antibody to Pneumocystis jirovecii","volume":"85","author":"Tesini","year":"2017","journal-title":"Infect Immun"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200861"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1086\/315487"},{"issue":"12","key":"B7","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.91894","article-title":"Murine 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