{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:33:28Z","timestamp":1792787608031,"version":"4.5.0"},"reference-count":61,"publisher":"American Society for Clinical Investigation","issue":"18","license":[{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH\/NCI","award":["CA217648,CA123088,CA099985,CA193136,CA152470"],"award-info":[{"award-number":["CA217648,CA123088,CA099985,CA193136,CA152470"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,17]]},"abstract":"<jats:p>\n                    Tumor-associated macrophages (TAMs) affect cancer progression and therapy. Ovarian carcinoma often metastasizes to the peritoneal cavity. Here, we found 2 peritoneal macrophage subsets in mice bearing ID8 ovarian cancer based on T cell immunoglobulin and mucin domain containing 4 (Tim-4) expression. Tim-4\n                    <jats:sup>+<\/jats:sup>\n                    TAMs were embryonically originated and locally sustained while Tim-4\n                    <jats:sup>\u2013<\/jats:sup>\n                    TAMs were replenished from circulating monocytes. Tim-4\n                    <jats:sup>+<\/jats:sup>\n                    TAMs, but not Tim-4\n                    <jats:sup>\u2013<\/jats:sup>\n                    TAMs, promoted tumor growth in vivo. Relative to Tim-4\n                    <jats:sup>\u2013<\/jats:sup>\n                    TAMs, Tim-4\n                    <jats:sup>+<\/jats:sup>\n                    TAMs manifested high oxidative phosphorylation and adapted mitophagy to alleviate oxidative stress. High levels of arginase-1 in Tim-4\n                    <jats:sup>+<\/jats:sup>\n                    TAMs contributed to potent mitophagy activities via weakened mTORC1 activation due to low arginine resultant from arginase-1\u2013mediated metabolism. Furthermore, genetic deficiency of autophagy element FAK family-interacting protein of 200 kDa resulted in Tim-4\n                    <jats:sup>+<\/jats:sup>\n                    TAM loss via ROS-mediated apoptosis and elevated T cell immunity and ID8 tumor inhibition in vivo. Moreover, human ovarian cancer\u2013associated macrophages positive for complement receptor of the immunoglobulin superfamily (CRIg) were transcriptionally, metabolically, and functionally similar to murine Tim-4\n                    <jats:sup>+<\/jats:sup>\n                    TAMs. Thus, targeting CRIg\n                    <jats:sup>+<\/jats:sup>\n                    (Tim-4\n                    <jats:sup>+<\/jats:sup>\n                    ) TAMs may potentially treat patients with ovarian cancer with peritoneal metastasis.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.141115","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T12:20:47Z","timestamp":1597148447000},"source":"Crossref","is-referenced-by-count":123,"title":["Autophagic adaptation to oxidative stress alters peritoneal residential macrophage survival and ovarian cancer metastasis"],"prefix":"10.1172","volume":"5","author":[{"given":"Houjun","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Surgery,"},{"name":"Center of Excellence for Cancer Immunology and Immunotherapy, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Surgery,"},{"name":"Center of Excellence for Cancer Immunology and Immunotherapy, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Surgery,"},{"name":"Center of Excellence for Cancer Immunology and Immunotherapy, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weichao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery,"},{"name":"Center of Excellence for Cancer Immunology and Immunotherapy, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9599-9907","authenticated-orcid":true,"given":"Yingjie","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Surgery,"},{"name":"Center of Excellence for Cancer Immunology and Immunotherapy, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2703-5268","authenticated-orcid":true,"given":"Shuang","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Surgery,"},{"name":"Center of Excellence for Cancer Immunology and Immunotherapy, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Grove","sequence":"additional","affiliation":[{"name":"Department of Surgery,"},{"name":"Center of Excellence for Cancer Immunology and Immunotherapy, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery,"},{"name":"Center of Excellence for Cancer Immunology and Immunotherapy, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Vatan","sequence":"additional","affiliation":[{"name":"Department of Surgery,"},{"name":"Center of Excellence for Cancer Immunology and Immunotherapy, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8244-227X","authenticated-orcid":true,"given":"J. Rebecca","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7833-1967","authenticated-orcid":true,"given":"Karen","family":"McLean","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramandeep","family":"Rattan","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health Services, Henry Ford Health System, Detroit, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Munkarah","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health Services, Henry Ford Health System, Detroit, Michigan, 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