{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:33:23Z","timestamp":1793655203168,"version":"4.5.1"},"reference-count":31,"publisher":"American Society for Clinical Investigation","issue":"5","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000191","name":"Kidney Foundation of Canada","doi-asserted-by":"crossref","award":["130024"],"award-info":[{"award-number":["130024"]}],"id":[{"id":"10.13039\/501100000191","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009227","name":"Department of Medicine, University of Toronto","doi-asserted-by":"crossref","award":["Challenge Grant"],"award-info":[{"award-number":["Challenge Grant"]}],"id":[{"id":"10.13039\/501100009227","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["Foundation 159922"],"award-info":[{"award-number":["Foundation 159922"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,8]]},"abstract":"<jats:p>\n                    IgA nephropathy (IgAN) is a leading cause of kidney failure, yet little is known about the immunopathogenesis of this disease. IgAN is characterized by deposition of IgA in the kidney glomeruli, but the source and stimulus for IgA production are not known. Clinical and experimental data suggest a role for aberrant immune responses to mucosal microbiota in IgAN, and in some countries with high disease prevalence, tonsillectomy is regarded as standard-of-care therapy. To evaluate the relationship between microbiota and mucosal immune responses, we characterized the tonsil microbiota in patients with IgAN versus nonrelated household-matched control group participants and identified increased carriage of the genus\n                    <jats:italic>Neisseria<\/jats:italic>\n                    and elevated\n                    <jats:italic>Neisseria<\/jats:italic>\n                    -targeted serum IgA in IgAN patients. We reverse-translated these findings in experimental IgAN driven by BAFF overexpression in BAFF-transgenic mice rendered susceptible to\n                    <jats:italic>Neisseria<\/jats:italic>\n                    infection by introduction of a humanized CEACAM-1 transgene (B \u00d7 hC-Tg). Colonization of B \u00d7 hC-Tg mice with\n                    <jats:italic>Neisseria<\/jats:italic>\n                    yielded augmented levels of systemic\n                    <jats:italic>Neisseria<\/jats:italic>\n                    -specific IgA. Using a custom ELISPOT assay, we discovered anti-\n                    <jats:italic>Neisseria<\/jats:italic>\n                    \u2013specific IgA-secreting cells within the kidneys of these mice. These findings suggest a role for cytokine-driven aberrant mucosal immune responses to oropharyngeal pathobionts, such as\n                    <jats:italic>Neisseria,<\/jats:italic>\n                    in the immunopathogenesis of IgAN. Furthermore, in the presence of excess BAFF, pathobiont-specific IgA can be produced in situ within the kidney.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.141289","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T12:07:15Z","timestamp":1644322035000},"source":"Crossref","is-referenced-by-count":55,"title":["Immunoglobulin A nephropathy is characterized by anticommensal humoral immune responses"],"prefix":"10.1172","volume":"7","author":[{"given":"Elissa G.","family":"Currie","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0150-4510","authenticated-orcid":true,"given":"Bryan","family":"Coburn","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa 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