{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:26:18Z","timestamp":1787631978354,"version":"build-2736575974"},"reference-count":45,"publisher":"American Society for Clinical Investigation","issue":"11","license":[{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P50AA024333,U01AA020821,U01AA026938,R01AA023722,R01AR049610,K99AA026648"],"award-info":[{"award-number":["P50AA024333,U01AA020821,U01AA026938,R01AA023722,R01AR049610,K99AA026648"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"crossref","award":["File:201806280215"],"award-info":[{"award-number":["File:201806280215"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,8]]},"abstract":"<jats:p>\n                    The chemokine system of ligands and receptors is implicated in the progression of alcohol-associated hepatitis (AH). Finding upstream regulators could lead to novel therapies. This study involved coordinated expression of chemokines in livers of healthy controls (HC) and patients with AH in 2 distinct cohorts of patients with various chronic liver diseases. Studies in cultured hepatocytes and in tissue-specific KO were used for mechanistic insight into a potential upstream regulator of chemokine expression in AH. Selected C-X-C chemokine members of the IL-8 chemokine family and C-C chemokine\n                    <jats:italic>CCL20<\/jats:italic>\n                    were highly associated with AH compared with HC but not in patients with liver diseases of other etiologies (nonalcoholic fatty liver disease [NAFLD] and hepatitis C virus [HCV]). Our previous studies implicate macrophage migration inhibitory factor (MIF) as a pleiotropic cytokine\/chemokine with the potential to coordinately regulate chemokine expression in AH. LPS-stimulated expression of multiple chemokines in cultured hepatocytes was dependent on MIF. Gao-binge ethanol feeding to mice induced a similar coordinated chemokine expression in livers of WT mice; this was prevented in hepatocyte-specific\n                    <jats:italic>Mif<\/jats:italic>\n                    \u2013KO (\n                    <jats:italic>Mif<\/jats:italic>\n                    <jats:italic\/>\n                    <jats:sup>\u0394Hep<\/jats:sup>\n                    <jats:italic\/>\n                    ) mice. This study demonstrates that patients with AH exhibit a specific, coordinately expressed chemokine signature and that hepatocyte-derived MIF might drive this inflammatory response.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.141420","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T12:00:44Z","timestamp":1620129644000},"source":"Crossref","is-referenced-by-count":5,"title":["Role of MIF in coordinated expression of hepatic chemokines in patients with alcohol-associated hepatitis"],"prefix":"10.1172","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3218-8418","authenticated-orcid":true,"given":"Kyle L.","family":"Poulsen","sequence":"first","affiliation":[{"name":"Center for Liver Disease Research, Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio, USA."},{"name":"Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, 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