{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:27:10Z","timestamp":1792189630791,"version":"4.4.0"},"reference-count":64,"publisher":"American Society for Clinical Investigation","issue":"13","license":[{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Austrian Research Fund","award":["P 28302"],"award-info":[{"award-number":["P 28302"]}]},{"name":"Austrian Research Fund","award":["P 33062"],"award-info":[{"award-number":["P 33062"]}]},{"name":"Austrian Research Fund","award":["I 3321 Epicross"],"award-info":[{"award-number":["I 3321 Epicross"]}]},{"name":"Austrian Research Fund","award":["W 1253 HOROS"],"award-info":[{"award-number":["W 1253 HOROS"]}]},{"DOI":"10.13039\/501100001822","name":"Austrian Academy of Sciences","doi-asserted-by":"crossref","award":["DOC stipend"],"award-info":[{"award-number":["DOC stipend"]}],"id":[{"id":"10.13039\/501100001822","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010105","name":"\u00d6sterreichische Krebshilfe Tirol","doi-asserted-by":"crossref","award":["15024"],"award-info":[{"award-number":["15024"]}],"id":[{"id":"10.13039\/501100010105","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Christian Doppler research Society","award":["AOP Orphan Pharmaceuticals AG"],"award-info":[{"award-number":["AOP Orphan Pharmaceuticals AG"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,8]]},"abstract":"<jats:p>\n                    Iron is an essential nutrient for mammals as well as for pathogens. Inflammation-driven changes in systemic and cellular iron homeostasis are central for host-mediated antimicrobial strategies. Here, we studied the role of the iron storage protein ferritin H (FTH) for the control of infections with the intracellular pathogen\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    serovar Typhimurium by macrophages. Mice lacking FTH in the myeloid lineage (\n                    <jats:italic>\n                      LysM-Cre\n                      <jats:sup>+\/+<\/jats:sup>\n                      Fth\n                      <jats:sup>fl\/fl<\/jats:sup>\n                    <\/jats:italic>\n                    mice) displayed impaired iron storage capacities in the tissue leukocyte compartment, increased levels of labile iron in macrophages, and an accelerated macrophage-mediated iron turnover. While under steady-state conditions,\n                    <jats:italic>\n                      LysM-Cre\n                      <jats:sup>+\/+<\/jats:sup>\n                      Fth\n                      <jats:sup>+\/+<\/jats:sup>\n                    <\/jats:italic>\n                    and\n                    <jats:italic>\n                      LysM-Cre\n                      <jats:sup>+\/+<\/jats:sup>\n                      Fth\n                      <jats:sup>fl\/fl<\/jats:sup>\n                    <\/jats:italic>\n                    animals showed comparable susceptibility to\n                    <jats:italic>Salmonella<\/jats:italic>\n                    infection, i.v. iron supplementation drastically shortened survival of\n                    <jats:italic>\n                      LysM-Cre\n                      <jats:sup>+\/+<\/jats:sup>\n                      Fth\n                      <jats:sup>fl\/fl<\/jats:sup>\n                    <\/jats:italic>\n                    mice. Mechanistically, these animals displayed increased bacterial burden, which contributed to uncontrolled triggering of NF-\u03baB and inflammasome signaling and development of cytokine storm and death. Importantly, pharmacologic inhibition of the inflammasome and IL-1\u03b2 pathways reduced cytokine levels and mortality and partly restored infection control in iron-treated ferritin-deficient mice. These findings uncover incompletely characterized roles of ferritin and cellular iron turnover in myeloid cells in controlling bacterial spread and for modulating NF-\u03baB and inflammasome-mediated cytokine activation, which may be of vital importance in iron-overloaded individuals suffering from severe infections and sepsis.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.141760","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T14:01:34Z","timestamp":1625666494000},"source":"Crossref","is-referenced-by-count":32,"title":["Ferritin H deficiency deteriorates cellular iron handling and worsens Salmonella typhimurium infection by triggering hyperinflammation"],"prefix":"10.1172","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8028-1030","authenticated-orcid":true,"given":"David","family":"Haschka","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, 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