{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:41:59Z","timestamp":1789609319971,"version":"build-2803163510"},"reference-count":43,"publisher":"American Society for Clinical Investigation","issue":"4","license":[{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NINDS, NIH","award":["Intramural Research Program of the NIH"],"award-info":[{"award-number":["Intramural Research Program of the NIH"]}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JSPS Research Fellowship for Japanese Biomedical"],"award-info":[{"award-number":["JSPS Research Fellowship for Japanese Biomedical"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["Behavioral Research"],"award-info":[{"award-number":["Behavioral Research"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,22]]},"abstract":"<jats:p>\n                    In this study, we examined and characterized disease-specific TCR signatures in cerebrospinal fluid (CSF) of patients with HTLV-1\u2013associated myelopathy\/tropical spastic paraparesis (HAM\/TSP). TCR \u03b2 libraries using unique molecular identifier\u2013based methodologies were sequenced in paired peripheral blood mononuclear cells (PBMCs) and CSF cells from HAM\/TSP patients and normal healthy donors (NDs). The sequence analysis demonstrated that TCR \u03b2 repertoires in CSF of HAM\/TSP patients were highly expanded and contained both TCR clonotypes shared with PBMCs and uniquely enriched within the CSF. In addition, we analyzed TCR \u03b2 repertoires of highly expanded and potentially immunopathologic HTLV-1 Tax11-19\u2013specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells from PBMCs of HLA-A*0201\n                    <jats:sup>+<\/jats:sup>\n                    HAM\/TSP and identified a conserved motif (PGLAG) in the CDR3 region. Importantly, TCR \u03b2 clonotypes of expanded clones in HTLV-1 Tax11-19\u2013specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells were also expanded and enriched in the CSF of the same patient. These results suggest that exploring TCR repertoires of CSF and antigen-specific T cells may provide a TCR repertoire signature in virus-associated neurologic disorders.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.144869","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T09:10:09Z","timestamp":1721293809000},"source":"Crossref","is-referenced-by-count":8,"title":["Immunopathogenic CSF TCR repertoire signatures in virus-associated neurologic disease"],"prefix":"10.1172","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4909-7769","authenticated-orcid":true,"given":"Satoshi","family":"Nozuma","sequence":"first","affiliation":[{"name":"Viral Immunology Section, Neuroimmunology Branch and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7102-9703","authenticated-orcid":true,"given":"Yoshimi","family":"Enose-Akahata","sequence":"additional","affiliation":[{"name":"Viral 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