{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:29:18Z","timestamp":1794000558449,"version":"4.8.0"},"reference-count":88,"publisher":"American Society for Clinical Investigation","issue":"18","license":[{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"vor","delay-in-days":118,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["U19AI089676,R21 AI142472,R01 AI114776,P41 GM109824"],"award-info":[{"award-number":["U19AI089676,R21 AI142472,R01 AI114776,P41 GM109824"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medical Research Council","award":["MR\/S009450\/1"],"award-info":[{"award-number":["MR\/S009450\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,22]]},"abstract":"<jats:p>\n                    Cerebral malaria (CM) affects children and adults, but brain swelling is more severe in children. To investigate features associated with brain swelling in malaria, we performed blood profiling and brain MRI in a cohort of pediatric and adult patients with CM in Rourkela, India, and compared them with an African pediatric CM cohort in Malawi. We determined that higher plasma\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    histidine rich protein 2 (PfHRP2) levels and elevated\n                    <jats:italic>var<\/jats:italic>\n                    transcripts that encode for binding to endothelial protein C receptor (EPCR) were linked to CM at both sites. Machine learning models trained on the African pediatric cohort could classify brain swelling in Indian children CM cases but had weaker performance for adult classification, due to overall lower parasite\n                    <jats:italic>var<\/jats:italic>\n                    transcript levels in this age group and more severe thrombocytopenia in Rourkela adults. Subgrouping of patients with CM revealed higher parasite biomass linked to severe thrombocytopenia and higher Group A\u2013EPCR\n                    <jats:italic>var<\/jats:italic>\n                    transcripts in mild thrombocytopenia. Overall, these findings provide evidence that higher parasite biomass and a subset of Group A\u2013EPCR binding variants are common features in children and adult CM cases, despite age differences in brain swelling.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.145823","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T14:01:23Z","timestamp":1632232883000},"source":"Crossref","is-referenced-by-count":43,"title":["Determinants of brain swelling in pediatric and adult cerebral malaria"],"prefix":"10.1172","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7855-7501","authenticated-orcid":true,"given":"Praveen K.","family":"Sahu","sequence":"first","affiliation":[{"name":"Center for the Study of Complex Malaria in India, Ispat General Hospital (IGH), Rourkela, Odisha, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4675-0937","authenticated-orcid":true,"given":"Fergal J.","family":"Duffy","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute, Seattle, Washington, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selasi","family":"Dankwa","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute, Seattle, Washington, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Vishnyakova","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute, Seattle, Washington, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megharay","family":"Majhi","sequence":"additional","affiliation":[{"name":"Department of Radiology, IGH, Rourkela, Odisha, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4390-9703","authenticated-orcid":true,"given":"Lukas","family":"Pirpamer","sequence":"additional","affiliation":[{"name":"Department of Infection Biology, London School of Hygiene & Tropical Medicine, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4195-4858","authenticated-orcid":true,"given":"Vladimir","family":"Vigdorovich","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute, Seattle, Washington, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jabamani","family":"Bage","sequence":"additional","affiliation":[{"name":"Center for the Study of Complex Malaria in India, Ispat General Hospital (IGH), Rourkela, Odisha, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Maharana","sequence":"additional","affiliation":[{"name":"Center for the Study of Complex Malaria in India, Ispat General Hospital (IGH), Rourkela, Odisha, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson","family":"Mandala","sequence":"additional","affiliation":[{"name":"Malawi University of Science and Technology, Limbe, Malawi."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4287-1982","authenticated-orcid":true,"given":"Stephen J.","family":"Rogerson","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Doherty Institute, University of Melbourne, Melbourne, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9859-9549","authenticated-orcid":true,"given":"Karl B.","family":"Seydel","sequence":"additional","affiliation":[{"name":"Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, USA."},{"name":"Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7416-3986","authenticated-orcid":true,"given":"Terrie E.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, USA."},{"name":"Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kami","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and International Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9128-172X","authenticated-orcid":true,"given":"D. 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