{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:12:50Z","timestamp":1793653970840,"version":"4.5.1"},"reference-count":65,"publisher":"American Society for Clinical Investigation","issue":"11","license":[{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["P2BSP3_188162"],"award-info":[{"award-number":["P2BSP3_188162"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institutes of Health National Cancer Institute","award":["U01CA247548,P01CA018029"],"award-info":[{"award-number":["U01CA247548,P01CA018029"]}]},{"name":"NIH\/NCI Cancer Center Support Grants","award":["P30CA0087-48,P30CA015704-44"],"award-info":[{"award-number":["P30CA0087-48,P30CA015704-44"]}]},{"DOI":"10.13039\/100015394","name":"American Society for Transplantation and Cellular Therapy","doi-asserted-by":"crossref","award":["-"],"award-info":[{"award-number":["-"]}],"id":[{"id":"10.13039\/100015394","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100014561","name":"Juno Therapeutics","doi-asserted-by":"crossref","award":["-"],"award-info":[{"award-number":["-"]}],"id":[{"id":"10.13039\/100014561","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Little is known about pathogen-specific humoral immunity after chimeric antigen receptor\u2013modified T (CAR-T) cell therapy for B cell malignancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We conducted a prospective cross-sectional study of CD19-targeted or B cell maturation antigen\u2013targeted (BCMA-targeted) CAR-T cell therapy recipients at least 6 months posttreatment and in remission. We measured pathogen-specific IgG against 12 vaccine-preventable infections and the number of viral and bacterial epitopes to which IgG was detected (\u201cepitope hits\u201d) using a serological profiling assay. The primary outcome was the proportion of participants with IgG levels above a threshold correlated with seroprotection for vaccine-preventable infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      We enrolled 65 children and adults a median of 20 months after CD19- (\n                      <jats:italic>n<\/jats:italic>\n                      = 54) or BCMA- (\n                      <jats:italic>n<\/jats:italic>\n                      = 11) CAR-T cell therapy. Among 30 adults without IgG replacement therapy (IGRT) in the prior 16 weeks, 27 (90%) had hypogammaglobulinemia. These individuals had seroprotection to a median of 67% (IQR, 59%\u201373%) of tested infections. Proportions of participants with seroprotection per pathogen were comparable to population-based studies, but most individuals lacked seroprotection to specific pathogens. Compared with CD19-CAR-T cell recipients, BCMA-CAR-T cell recipients were half as likely to have seroprotection (prevalence ratio, 0.47; 95% CI, 0.18\u20131.25) and had fewer pathogen-specific epitope hits (mean difference, \u201390 epitope hits; 95% CI, \u2013157 to \u201322).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Seroprotection for vaccine-preventable infections in adult CD19-CAR-T cell recipients was comparable to the general population. BCMA-CAR-T cell recipients had fewer pathogen-specific antibodies. Deficits in both groups support the need for vaccine and immunoglobulin replacement therapy studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>FUNDING<\/jats:title>\n                    <jats:p>Swiss National Science Foundation (Early Postdoc Mobility grant P2BSP3_188162), NIH\/National Cancer Institute (NIH\/NCI) (U01CA247548 and P01CA018029), NIH\/NCI Cancer Center Support Grants (P30CA0087-48 and P30CA015704-44), American Society for Transplantation and Cellular Therapy, and Juno Therapeutics\/BMS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1172\/jci.insight.146743","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T12:01:20Z","timestamp":1619697680000},"source":"Crossref","is-referenced-by-count":46,"title":["Antibodies against vaccine-preventable infections after CAR-T cell therapy for B cell malignancies"],"prefix":"10.1172","volume":"6","author":[{"given":"Carla 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