{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:19:07Z","timestamp":1790633947205,"version":"4.1.0"},"reference-count":54,"publisher":"American Society for Clinical Investigation","issue":"7","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"crossref","award":["DK082866"],"award-info":[{"award-number":["DK082866"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"crossref","award":["DK082866"],"award-info":[{"award-number":["DK082866"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,8]]},"abstract":"<jats:p>\n                    Studies of human hepatitis B virus (HBV) immune pathogenesis are hampered by limited access to liver tissues and technologies for detailed analyses. Here, utilizing imaging mass cytometry (IMC) to simultaneously detect 30 immune, viral, and structural markers in liver biopsies from patients with hepatitis B e antigen\n                    <jats:sup>+<\/jats:sup>\n                    (HBeAg\n                    <jats:sup>+<\/jats:sup>\n                    ) chronic hepatitis B, we provide potentially novel comprehensive visualization, quantitation, and phenotypic characterizations of hepatic adaptive and innate immune subsets that correlated with hepatocellular injury, histological fibrosis, and age. We further show marked correlations between adaptive and innate immune cell frequencies and phenotype, highlighting complex immune interactions within the hepatic microenvironment with relevance to HBV pathogenesis.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.146883","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T17:19:55Z","timestamp":1614446395000},"source":"Crossref","is-referenced-by-count":37,"title":["Highly multiplexed 2-dimensional imaging mass cytometry analysis of HBV-infected liver"],"prefix":"10.1172","volume":"6","author":[{"given":"Daniel","family":"Traum","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA."},{"name":"Medical Research, The Corporal Michael J. 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