{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T12:33:30Z","timestamp":1782131610054,"version":"3.54.5"},"reference-count":49,"publisher":"American Society for Clinical Investigation","issue":"18","license":[{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Cancer Institute","award":["Intramural grant"],"award-info":[{"award-number":["Intramural grant"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,22]]},"abstract":"<jats:p>\n                    Invariant NKT (\n                    <jats:italic>i<\/jats:italic>\n                    NKT) cells are potent immunomodulatory cells that acquire effector function during their development in the thymus. IL-17\u2013producing\n                    <jats:italic>i<\/jats:italic>\n                    NKT cells are commonly referred to as NKT17 cells, and they are unique among\n                    <jats:italic>i<\/jats:italic>\n                    NKT cells to express the heparan sulfate proteoglycan CD138 and the transcription factor ROR\u03b3t. Whether and how CD138 and ROR\u03b3t contribute to NKT17 cell differentiation, and whether there is an interplay between ROR\u03b3t and CD138 expression to control\n                    <jats:italic>i<\/jats:italic>\n                    NKT lineage fate, remain mostly unknown. Here, we showed that CD138 expression was only associated with and not required for the differentiation and IL-17 production of NKT17 cells. Consequently, CD138-deficient mice still generated robust numbers of IL-17\u2013producing ROR\u03b3t\n                    <jats:sup>+<\/jats:sup>\n                    NKT17 cells. Moreover, forced expression of ROR\u03b3t significantly promoted the generation of thymic NKT17 cells, but did not induce CD138 expression on non-NKT17 cells. These results indicated that NKT17 cell generation and IL-17 production were driven by ROR\u03b3t, employing mechanisms that were independent of CD138. Therefore, our study effectively dissociated CD138 expression from the ROR\u03b3t-driven molecular pathway of NKT17 cell differentiation.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.148038","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T14:01:23Z","timestamp":1632232883000},"source":"Crossref","is-referenced-by-count":7,"title":["CD138 expression is a molecular signature but not a developmental requirement for ROR\u03b3t+ NKT17 cells"],"prefix":"10.1172","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5728-2112","authenticated-orcid":true,"given":"Shunqun","family":"Luo","sequence":"first","affiliation":[{"name":"Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntae","family":"Kwon","sequence":"additional","affiliation":[{"name":"Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5746-0073","authenticated-orcid":true,"given":"Assiatu","family":"Crossman","sequence":"additional","affiliation":[{"name":"Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7979-4979","authenticated-orcid":true,"given":"Pyong Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9547-9055","authenticated-orcid":true,"given":"Jung-Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Experimental Immunology Branch, Center for Cancer 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