{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:09:30Z","timestamp":1779149370906,"version":"3.51.4"},"reference-count":40,"publisher":"American Society for Clinical Investigation","issue":"3","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81670166,81530046"],"award-info":[{"award-number":["81670166,81530046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Innovative Research Groups of the National Natural Science Foundation of China","award":["81621001"],"award-info":[{"award-number":["81621001"]}]},{"name":"the National Key Research and Development Program of China","award":["2017YFA0104500"],"award-info":[{"award-number":["2017YFA0104500"]}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science & Technology Commission","doi-asserted-by":"crossref","award":["Z171100001017098"],"award-info":[{"award-number":["Z171100001017098"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the project of health collaborative innovation of Guangzhou city","award":["201704020214"],"award-info":[{"award-number":["201704020214"]}]},{"name":"Scientific Research Foundation for Capital Medicine Development","award":["2018-2-4084"],"award-info":[{"award-number":["2018-2-4084"]}]},{"name":"Peking University Clinical Scientist Program","award":["BMU2019LCKXJ003"],"award-info":[{"award-number":["BMU2019LCKXJ003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,8]]},"abstract":"<jats:p>\n                    CMV infection remains an important cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Several investigators have reported that adaptive NKG2C\n                    <jats:sup>+<\/jats:sup>\n                    NK cells persistently expand during CMV reactivation. In our study, 2 cohorts were enrolled to explore the relationships among the\n                    <jats:italic>NKG2C<\/jats:italic>\n                    genotype, NKG2C\n                    <jats:sup>+<\/jats:sup>\n                    NK cell reconstitution, and CMV infection. Multivariate analysis showed that donor\n                    <jats:italic>NKG2C<\/jats:italic>\n                    gene deletion was an independent prognostic factor for CMV reactivation and refractory CMV reactivation. Furthermore, adaptive NKG2C\n                    <jats:sup>+<\/jats:sup>\n                    NK cells\u2019 quantitative and qualitative reconstitution, along with their anti-CMV function after transplantation, was significantly lower in patients grafted with\n                    <jats:italic>\n                      NKG2C\n                      <jats:sup>wt\/del<\/jats:sup>\n                    <\/jats:italic>\n                    donor cells than in those grafted with\n                    <jats:italic>\n                      NKG2C\n                      <jats:sup>wt\/wt<\/jats:sup>\n                    <\/jats:italic>\n                    donor cells. At day 30 after transplantation, quantitative reconstitution of NKG2C\n                    <jats:sup>+<\/jats:sup>\n                    NK cells was significantly lower in patients with treatment-refractory CMV reactivation than in patients without CMV reactivation and those with nonrefractory CMV reactivation. In humanized CMV-infected mice, we found that, compared with those from\n                    <jats:italic>\n                      NKG2C\n                      <jats:sup>wt\/del<\/jats:sup>\n                    <\/jats:italic>\n                    donors, adaptive NKG2C\n                    <jats:sup>+<\/jats:sup>\n                    NK cells from\n                    <jats:italic>\n                      NKG2C\n                      <jats:sup>wt\/wt<\/jats:sup>\n                    <\/jats:italic>\n                    donors induced earlier and stronger expansion of NKG2C\n                    <jats:sup>+<\/jats:sup>\n                    NK cells as well as earlier and stronger CMV clearance in vivo. In conclusion, donor\n                    <jats:italic>NKG2C<\/jats:italic>\n                    homozygosity contributes to CMV clearance by promoting the quantitative and qualitative reconstruction of adaptive NKG2C\n                    <jats:sup>+<\/jats:sup>\n                    NK cells after haploidentical allo-HSCT.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.149120","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T12:01:16Z","timestamp":1641470476000},"source":"Crossref","is-referenced-by-count":17,"title":["Donor NKG2C homozygosity contributes to CMV clearance after haploidentical transplantation"],"prefix":"10.1172","volume":"7","author":[{"given":"Xing-Xing","family":"Yu","sequence":"first","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China."},{"name":"Peking-Tsinghua Center for Life Sciences, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian-Nan","family":"Shang","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China."},{"name":"Peking-Tsinghua Center for Life Sciences, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China."},{"name":"Peking-Tsinghua Center for Life Sciences, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"He","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu-Ying","family":"Pei","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Dong","family":"Mo","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6625-9523","authenticated-orcid":true,"given":"Meng","family":"Lv","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Ting","family":"Han","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, 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