{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:42:47Z","timestamp":1790095367166,"version":"4.0.1"},"reference-count":57,"publisher":"American Society for Clinical Investigation","issue":"13","license":[{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Health","award":["R03DK114465,R21HD100840,R01DK115720"],"award-info":[{"award-number":["R03DK114465,R21HD100840,R01DK115720"]}]},{"DOI":"10.13039\/100011123","name":"Academic Health Center, University of Minnesota","doi-asserted-by":"crossref","award":["Regenerative Medicine Minnesota"],"award-info":[{"award-number":["Regenerative Medicine Minnesota"]}],"id":[{"id":"10.13039\/100011123","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,8]]},"abstract":"<jats:p>\n                    Fetal growth restriction, or low birth weight, is a strong determinant for eventual obesity and type 2 diabetes. Clinical studies suggest placental mechanistic target of rapamycin (mTOR) signaling regulates fetal birth weight and the metabolic health trajectory of the offspring. In the current study, we used a genetic model with loss of placental mTOR function (mTOR-KO\n                    <jats:sup>Placenta<\/jats:sup>\n                    ) to test the direct role of mTOR signaling on birth weight and metabolic health in the adult offspring. mTOR-KO\n                    <jats:sup>Placenta<\/jats:sup>\n                    animals displayed reduced placental area and total weight, as well as fetal body weight at embryonic day (E) 17.5. Birth weight and serum insulin levels were reduced; however, \u03b2 cell mass was normal in mTOR-KO\n                    <jats:sup>Placenta<\/jats:sup>\n                    newborns. Adult mTOR-KO\n                    <jats:sup>Placenta<\/jats:sup>\n                    offspring, under a metabolic high-fat challenge, displayed exacerbated obesity and metabolic dysfunction compared with littermate controls. Subsequently, we tested whether enhancing placental mTOR complex 1 (mTORC1) signaling, via genetic ablation of TSC2, in utero would improve glucose homeostasis in the offspring. Indeed, increased placental mTORC1 conferred protection from diet-induced obesity in the offspring. In conclusion, placental mTORC1 serves as a mechanistic link between placental function and programming of obesity and insulin resistance in the adult offspring.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.149271","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T12:01:20Z","timestamp":1621944080000},"source":"Crossref","is-referenced-by-count":35,"title":["Placental mTOR complex 1 regulates fetal programming of obesity and insulin resistance in mice"],"prefix":"10.1172","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1268-6623","authenticated-orcid":true,"given":"Brian","family":"Akhaphong","sequence":"first","affiliation":[{"name":"Department of Integrative Biology & Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3669-2064","authenticated-orcid":true,"given":"Daniel 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